S. O. Vardanyan, A. S. Avagyan, A. B. Sargsyan, H. A. Panosyan, S. A. Harutyunyan, H. V. Gasparyan, A. A. Aghekyan
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Synthesis and Antihypoxic Properties of New 2-(1,4-Benzodioxan-2-yl)-1,3,4-oxadiazole Derivatives
The condensation of previously described 1,4-benzodioxane-2-carbohydrazide with various 1-(substituted phenyl)cycloalkan-1-carbonyl chlorides, as well as 4-aryltetrahydropyran-4-carbonyl chloride gave N,N′-diacylhydrazines which were cyclized by the action of phosphoryl chloride to the corresponding 2-(1,4-benzodioxan-2-yl)-1,3,4-oxadiazole derivatives. The synthesized compounds were evaluated for antihypoxic activity.
期刊介绍：
Russian Journal of Organic Chemistry is an international peer reviewed journal that covers all aspects of modern organic chemistry including organic synthesis, theoretical organic chemistry, structure and mechanism, and the application of organometallic compounds in organic synthesis.
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