硫康唑电荷转移配合物的组成和结构对其光谱特性和抗癌活性的影响

IF 0.7 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY Theoretical and Experimental Chemistry Pub Date : 2024-10-31 DOI:10.1007/s11237-024-09817-5

Eman Yossri Frag, Asmaa M. Mahmoud, Marwa El-Badry Mohamed

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引用次数: 0

摘要

研究表明，电子供体替康唑（TCZ）与π受体氯苯胺酸、2,3-二氯-5,6-二氰基-1,4-苯醌和苦味酸相互作用会形成电荷转移复合物。利用光谱方法对所获得的配合物进行了表征，并通过 DFT 揭示了其结构的具体特征。研究发现，这些复合物对乳腺癌细胞株（MCF-7）具有细胞毒性活性，其 IC50 标准效率超过了单个 TCZ 的效率。

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Influence of Composition and Structure of Charge Transfer Complexes of Tioconazole on Their Spectral Properties and Anticancer Activity

It is shown that interaction of electron donor tioconazole (TCZ) with π acceptors chloroanilic acid, 2,3-dichloro-5,6-dicyano-1,4-benzoquinone, and picric acid leads to formation of the charge transfer complexes. The obtained complexes are characterized by spectral methods, and specific features of their structure are revealed by DFT. It is found that such complexes possess cytotoxic activity against breast cancer line (MCF-7), and their efficiency on IC₅₀ criterion exceeds the efficiency of the individual TCZ.

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来源期刊

Theoretical and Experimental Chemistry CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

1.60

自引率

10.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Theoretical and Experimental Chemistry is a journal for the rapid publication of research communications and reviews on modern problems of physical chemistry such as: a) physicochemical bases, principles, and methods for creation of novel processes, compounds, and materials; b) physicochemical principles of chemical process control, influence of external physical forces on chemical reactions; c) physical nanochemistry, nanostructures and nanomaterials, functional nanomaterials, size-dependent properties of materials.