Fangyuan Chen, Sayali Onkar, Jian Zou, Yujia Li, Haley Arbore, Sai Maley, George Tseng, Peter C. Lucas, Tullia C. Bruno, Dario A. A. Vignali, Julia Foldi, Marija Balic, Adrian V. Lee, Steffi Oesterreich
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引用次数: 0
摘要
了解乳腺癌与微环境的相互作用至关重要。在这里，我们从 21 个 ER + /HER2- ILCs 的 RNA-seq 和多重免疫组化中确定了两种转录组亚型和五种免疫浸润模式。我们发现增殖亚型与抑制性免疫浸润增加有关，并定义了一个与较低增殖、促炎TAM浸润和ER+乳腺癌生存改善有关的特征。我们的研究发现了与ILC免疫微环境和预后相关的基因。
Immune infiltration correlates with transcriptomic subtypes in primary estrogen receptor positive invasive lobular breast cancer
Understanding interplay of breast cancer and microenvironment is critical. Here we identified two transcriptomic subtypes and five immune infiltration patterns from RNA-seq and multiplex immunohistochemistry from 21 ER + /HER2- ILCs. We found proliferative subtype associated with increased suppressive immune infiltration, and defined a signature associated with lower proliferative, pro-inflammatory TAM infiltration, and improved survival in ER+ breast cancer. Our work identified genes related to ILC immune microenvironment and prognosis.
期刊介绍：
Online-only and open access, npj Precision Oncology is an international, peer-reviewed journal dedicated to showcasing cutting-edge scientific research in all facets of precision oncology, spanning from fundamental science to translational applications and clinical medicine.
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