封面：利用混合三芳基甲烷靶向结直肠癌的可行方法（ChemMedChem 21/2024）

IF 3.6 4区医学 Q2 CHEMISTRY, MEDICINAL ChemMedChem Pub Date : 2024-11-05 DOI:10.1002/cmdc.202482101

Ameni Hadj Mohamed, Christophe Ricco, Aline Pinon, Nathalie Lagarde, Elizabeth Goya-Jorge, Hadley Mouhsine, Moncef Msaddek, Bertrand Liagre, Maité Sylla-Iyarreta Veitía

{"title":"封面：利用混合三芳基甲烷靶向结直肠癌的可行方法（ChemMedChem 21/2024）","authors":"Ameni Hadj Mohamed, Christophe Ricco, Aline Pinon, Nathalie Lagarde, Elizabeth Goya-Jorge, Hadley Mouhsine, Moncef Msaddek, Bertrand Liagre, Maité Sylla-Iyarreta Veitía","doi":"10.1002/cmdc.202482101","DOIUrl":null,"url":null,"abstract":"<p>The Front Cover features a potential inhibitor targeting the protein kinase B (AKT), N-oxide hybrid triarylmethane type. The mechanism of action of its antiproliferative activity was validated through in silico studies and biological tests on colorectal cancer cells lines. More details can be found in article 10.1002/cmdc.202400151 by Bertrand Liagre, M. Sylla-Iyarreta Veitía, and co-workers. Cover design was generated using the high-performance molecular visualization software VTX (https://vtx.drugdesign.fr).\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure>\n </p>","PeriodicalId":147,"journal":{"name":"ChemMedChem","volume":"19 21","pages":""},"PeriodicalIF":3.6000,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cmdc.202482101","citationCount":"0","resultStr":"{\"title\":\"Front Cover: A Promising Approach to Target Colorectal Cancer Using Hybrid Triarylmethanes (ChemMedChem 21/2024)\",\"authors\":\"Ameni Hadj Mohamed, Christophe Ricco, Aline Pinon, Nathalie Lagarde, Elizabeth Goya-Jorge, Hadley Mouhsine, Moncef Msaddek, Bertrand Liagre, Maité Sylla-Iyarreta Veitía\",\"doi\":\"10.1002/cmdc.202482101\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>The Front Cover features a potential inhibitor targeting the protein kinase B (AKT), N-oxide hybrid triarylmethane type. The mechanism of action of its antiproliferative activity was validated through in silico studies and biological tests on colorectal cancer cells lines. More details can be found in article 10.1002/cmdc.202400151 by Bertrand Liagre, M. Sylla-Iyarreta Veitía, and co-workers. Cover design was generated using the high-performance molecular visualization software VTX (https://vtx.drugdesign.fr).\\n <figure>\\n <div><picture>\\n <source></source></picture><p></p>\\n </div>\\n </figure>\\n </p>\",\"PeriodicalId\":147,\"journal\":{\"name\":\"ChemMedChem\",\"volume\":\"19 21\",\"pages\":\"\"},\"PeriodicalIF\":3.6000,\"publicationDate\":\"2024-11-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cmdc.202482101\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ChemMedChem\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/cmdc.202482101\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ChemMedChem","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cmdc.202482101","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}

引用次数: 0

摘要

封面介绍了一种针对蛋白激酶 B (AKT)的潜在抑制剂--N-氧化物混合三芳基甲烷型。其抗增殖活性的作用机制已通过硅学研究和对结直肠癌细胞系的生物测试得到验证。更多详情可参见 Bertrand Liagre、M. Sylla-Iyarreta Veitía 及合作者撰写的文章 10.1002/cmdc.202400151。封面设计由高性能分子可视化软件 VTX (https://vtx.drugdesign.fr) 生成。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

摘要图片

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

Front Cover: A Promising Approach to Target Colorectal Cancer Using Hybrid Triarylmethanes (ChemMedChem 21/2024)

The Front Cover features a potential inhibitor targeting the protein kinase B (AKT), N-oxide hybrid triarylmethane type. The mechanism of action of its antiproliferative activity was validated through in silico studies and biological tests on colorectal cancer cells lines. More details can be found in article 10.1002/cmdc.202400151 by Bertrand Liagre, M. Sylla-Iyarreta Veitía, and co-workers. Cover design was generated using the high-performance molecular visualization software VTX (https://vtx.drugdesign.fr).

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

ChemMedChem 医学-药学

CiteScore

6.70

自引率

2.90%

发文量

280

审稿时长

1 months

期刊介绍： Quality research. Outstanding publications. With an impact factor of 3.124 (2019), ChemMedChem is a top journal for research at the interface of chemistry, biology and medicine. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. ChemMedChem publishes primary as well as critical secondary and tertiary information from authors across and for the world. Its mission is to integrate the wide and flourishing field of medicinal and pharmaceutical sciences, ranging from drug design and discovery to drug development and delivery, from molecular modeling to combinatorial chemistry, from target validation to lead generation and ADMET studies. ChemMedChem typically covers topics on small molecules, therapeutic macromolecules, peptides, peptidomimetics, and aptamers, protein-drug conjugates, nucleic acid therapies, and beginning 2017, nanomedicine, particularly 1) targeted nanodelivery, 2) theranostic nanoparticles, and 3) nanodrugs. Contents ChemMedChem publishes an attractive mixture of: Full Papers and Communications Reviews and Minireviews Patent Reviews Highlights and Concepts Book and Multimedia Reviews.