来那度胺-硼替佐米-地塞米松诱导疗法对新诊断多发性骨髓瘤肾功能损害患者的影响:Connect® MM登记的结果

IF 12.9 1区 医学 Q1 HEMATOLOGY Blood Cancer Journal Pub Date : 2024-11-11 DOI:10.1038/s41408-024-01177-6
Sikander Ailawadhi, Hans C. Lee, James Omel, Kathleen Toomey, James W. Hardin, Cristina J. Gasparetto, Sundar Jagannath, Robert M. Rifkin, Brian G. M. Durie, Mohit Narang, Howard R. Terebelo, Prashant Joshi, Ying-Ming Jou, Jorge Mouro, Edward Yu, Rafat Abonour
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引用次数: 0

摘要

有关新诊断多发性骨髓瘤(NDMM)和肾功能损害(RI)患者诱导治疗效果的数据有限,这些患者可能还不符合自体干细胞移植条件。这项分析调查了来那度胺-硼替佐米-地塞米松(RVd)诱导治疗对Connect® MM登记处患者肾功能的影响,根据的是移植状态。符合条件的患者年龄≥18岁,入组前≤2个月确诊为无症状MM。本分析中的患者接受了≥3个周期的一线RVd治疗,并按移植状态和基线肾功能分组。截至2021年8月4日,344名移植患者和289名非移植患者在诱导时接受了≥3个周期的RVd治疗。在3、6和12个月时,观察到基线RI所有严重程度的患者肾功能均有所改善。在基线肌酐清除率为>60和≤60 mL/min的患者中,移植患者的中位无进展生存期分别为49.4个月和47.6个月,非移植患者的中位无进展生存期分别为35.7个月和29.1个月。这些结果提供了真实世界的证据,即无论移植状态如何,接受一线RVd治疗≥3个周期的NDMM和RI患者的肾功能都可能得到改善,肾功能不再影响长期预后。临床试验信息:NCT01081028。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Impact of lenalidomide-bortezomib-dexamethasone induction on patients with newly diagnosed multiple myeloma and renal impairment: Results from the Connect® MM Registry

Limited data exist on the effects of induction treatment in patients with newly diagnosed multiple myeloma (NDMM) and renal impairment (RI), who may also be ineligible for autologous stem cell transplant. This analysis investigated the impact of lenalidomide-bortezomib-dexamethasone (RVd) induction on renal function in patients from the Connect® MM Registry based on transplant status. Eligible patients were aged ≥18 years with symptomatic MM diagnosed ≤2 months before enrollment. Patients in this analysis received front-line RVd for ≥3 cycles and were grouped by transplant status and baseline renal function. As of August 4, 2021, 344 transplanted and 289 non-transplanted patients had received RVd for ≥3 cycles at induction. Improved renal function was observed at 3, 6, and 12 months in patients with all severities of RI at baseline. In patients with >60 and ≤60 creatinine clearance mL/min at baseline, median progression-free survival was 49.4 months and 47.6 months in transplanted patients and 35.7 months and 29.1 months in non-transplanted patients, respectively. These results provide real-world evidence that patients with NDMM and RI who receive front-line RVd for ≥3 cycles may have improved renal function regardless of transplant status, with renal function no longer affecting the long-term outcome. Clinical trial information: NCT01081028.

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来源期刊
CiteScore
16.70
自引率
2.30%
发文量
153
审稿时长
>12 weeks
期刊介绍: Blood Cancer Journal is dedicated to publishing high-quality articles related to hematologic malignancies and related disorders. The journal welcomes submissions of original research, reviews, guidelines, and letters that are deemed to have a significant impact in the field. While the journal covers a wide range of topics, it particularly focuses on areas such as: Preclinical studies of new compounds, especially those that provide mechanistic insights Clinical trials and observations Reviews related to new drugs and current management of hematologic malignancies Novel observations related to new mutations, molecular pathways, and tumor genomics Blood Cancer Journal offers a forum for expedited publication of novel observations regarding new mutations or altered pathways.
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