基于三维自支撑 TiO2/CdS/BiOI Z 型异质结的新型甲胎蛋白检测光电化学传感器

IF 2.7 3区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY New Journal of Chemistry Pub Date : 2024-10-28 DOI:10.1039/D4NJ03779K
Jinxin Li, Tao Jing, Haiyan Qi, Yunpeng Zhao, Yao Wang and Linfeng Fan
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引用次数: 0

摘要

甲胎蛋白(AFP)是肝癌的特征性标志物,其准确检测对肝癌的早期发现具有重要意义。本研究利用可见光作为激发光源,采用电化学测量方法,并结合甲胎蛋白适配体作为生物识别元件,构建了一种高灵敏度检测甲胎蛋白的光电化学(PEC)生物传感器。通过两步水热法构建了 Z 型异质结构,并将 CdS 纳米颗粒锚定在高比表面积的 TiO2NRA 和 BiOI 纳米片上。BiOI/CdS/TiO2NRA 复合材料的光电流响应是 TiO2NRA 的 4.5 倍。通过分析能带位置,阐明了 CdS/TiO2NRA 和 BiOI/CdS 光活性材料中 Z 型异质结的电子传递机制。随后,通过 CN 结构将 AFP 合体固定在基底电极表面,制造出一个自支撑传感平台。该 PEC 生物传感器在 1 nM ∼ 250 nM 的线性范围内表现出优异的检测性能和高选择性,检测限为 0.59 nM(S/N = 3)。它被有效地用于检测血液中的甲胎蛋白,为肝癌的早期检测和预防提供了一种实用的方法,同时也为设计其他类似的特征标记生物传感器提供了新的启示。
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A novel photoelectrochemical aptasensor for alpha-fetoprotein assay based on a 3D self-supporting TiO2/CdS/BiOI Z-scheme heterojunction

Alpha-fetoprotein (AFP) is a characteristic marker of liver cancer, and its accurate detection is of great significance for the early detection of liver cancer. This study utilizes visible light as the excitation light source, employs electrochemical measurement, and incorporates the AFP aptamer as the biorecognition element to construct a photoelectrochemical (PEC) biosensor for the highly sensitive detection of AFP. A Z-scheme heterostructure is constructed via a two-step hydrothermal method, and CdS nanoparticles are anchored on TiO2NRA and BiOI nanosheets with high specific surface areas. The photocurrent response of the BiOI/CdS/TiO2NRA composite material is 4.5 times that of TiO2NRA. By analyzing the energy band positions, the electron transfer mechanisms of Z-scheme heterojunctions in CdS/TiO2NRA and BiOI/CdS photoactive materials were elucidated. Subsequently, the AFP aptamer was immobilized on the base electrode surface via the CN structure to fabricate a self-supporting sensing platform. The PEC biosensor demonstrates excellent detection performance within the linear range of 1 nM ∼ 250 nM, exhibiting high selectivity and the detection limit is 0.59 nM (S/N = 3). It has been effectively utilized for the detection of AFP in blood, providing a practical method for early detection and prevention of liver cancer, and also offering new insights for the design of other similar characteristic marker biosensors.

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来源期刊
New Journal of Chemistry
New Journal of Chemistry 化学-化学综合
CiteScore
5.30
自引率
6.10%
发文量
1832
审稿时长
2 months
期刊介绍: A journal for new directions in chemistry
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