血浆胶质纤维酸性蛋白在唐氏综合征淀粉样蛋白和 tau 病理学中的中介作用

IF 13 1区医学 Q1 CLINICAL NEUROLOGY Alzheimer's & Dementia Pub Date : 2024-11-13 DOI:10.1002/alz.14359

Anna H. Boerwinkle, Julie K. Wisch, Benjamin L. Handen, Elizabeth Head, Mark Mapstone, Michael S. Rafii, Sid E. O'Bryant, Sharon J. Krinsky-McHale, Florence Lai, H. Diana Rosas, Shahid Zaman, Ira T. Lott, Dana Tudorascu, Matthew Zammit, Adam M. Brickman, Joseph H. Lee, Beau M. Ances

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引用次数: 0

摘要

与散发性或其他遗传性阿尔茨海默病（AD）相比，唐氏综合征（DS）患者的阿尔茨海默病（AD）病理发展时间较短。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The mediating role of plasma glial fibrillary acidic protein in amyloid and tau pathology in Down's syndrome

Development of Alzheimer's disease (AD) pathology in Down's syndrome (DS) occurs within a compressed timeline compared to sporadic or other genetic forms of AD.

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.