奶牛瘤胃微生物组中特定功能群的宿主遗传调控:对泌乳性状的影响

IF 11.4 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Journal of Advanced Research Pub Date : 2024-11-12 DOI:10.1016/j.jare.2024.11.012
Hao Bai, Zheng Lai, Jiawei Zhang, Xinyi Zheng, Jiyou Zhang, Wei Jin, Limei Lin, Shengyong Mao
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引用次数: 0

摘要

导言反刍动物将工业副产品和植物纤维中的非消耗物质转化为肉和奶等宝贵资源,在我们的社会中发挥着举足轻重的作用。这种非凡的转化能力主要归功于瘤胃微生物群,而瘤胃微生物群受各种因素的影响,包括饮食、气候和地理位置。近年来,越来越多的研究表明,宿主因素(品种、遗传变异等)在塑造牛的瘤胃微生物组成和功能方面也起着至关重要的作用。本研究旨在为进一步研究通过宿主遗传以及与瘤胃微生物群的相互作用来调节奶牛泌乳性状提供理论基础和机会。方法为了研究宿主基因型、瘤胃微生物群和动物表型之间的相互作用,我们对 1,169 头荷斯坦奶牛的奶牛群改良(DHI)数据、单核苷酸多态性(SNPs)基因型和 16S 瘤胃微生物群数据进行了整理和分析。结果我们发现了 31 个可遗传的类群,其功能主要集中在碳水化合物代谢和能量代谢方面。全基因组关联研究显示,九种可遗传细菌与 43 个 SNPs 显著相关。位于这些 SNPs 内或附近的功能基因主要与瘤胃上皮发育有关。此外,这九种遗传细菌主要被注释为复合多糖降解菌和丁酸盐生产菌,如 Fibrobacter sp900143055 和 Pseudoruminococcus massiliensis,它们与产奶量和乳脂率有显著相关性。与之前的研究相比,我们新发现了脐带奥尔森氏菌、洪氏丁弧菌等存在较高的遗传率。
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Host genetic regulation of specific functional groups in the rumen microbiome of dairy cows: Implications for lactation trait

Introduction

Ruminants play a pivotal role in our society by transforming non-consumable substances from industrial by-products and plant fibers into valuable resources such as meat and milk. This remarkable conversion ability is primarily attributed to the rumen microbiota, which is influenced by various factors, including diet, climate, and geographical location. In recent years, increasing research has shown that host factors (breed, genetic variation, etc.) also play vital roles in shaping rumen microbial composition and function in cattle.

Objective

This study aims to provide a theoretical basis and an opportunity for further investigating the regulation of lactation traits in dairy cows through host genetics and the interaction with the rumen microbiota.

Method

To investigate the interactions between host genotype, rumen microbiota, and animal phenotype, we curated and analyzed the dairy herd improvement (DHI) data, single nucleotide polymorphisms (SNPs) genotypes, and 16S rumen microbiota data from 1,169 Holstein dairy cows. Heritability and microbiability estimation, along with genome-wide association studies (GWAS) were performed to identify candidate microorganisms and host genetic loci.

Result

We identified thirty-one heritable taxa, whose functions were predominantly enriched in carbohydrate metabolism and energy metabolism. The genome-wide association study revealed that nine heritable bacteria were significantly associated with forty-three SNPs. Functional genes located within or near these SNPs were primarily associated with rumen epithelial development. Additionally, these nine heritable bacteria were primarily annotated as complex polysaccharide degraders and butyrate producers, such as Fibrobacter sp900143055 and Pseudoruminococcus massiliensis, which showed significant associations with milk yield and milk fat percentage. Compared to previous studies, we newly discovered the existence of a high heritability of Olsenella umbonate, Butyrivibrio hungatei, among others.
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来源期刊
Journal of Advanced Research
Journal of Advanced Research Multidisciplinary-Multidisciplinary
CiteScore
21.60
自引率
0.90%
发文量
280
审稿时长
12 weeks
期刊介绍: Journal of Advanced Research (J. Adv. Res.) is an applied/natural sciences, peer-reviewed journal that focuses on interdisciplinary research. The journal aims to contribute to applied research and knowledge worldwide through the publication of original and high-quality research articles in the fields of Medicine, Pharmaceutical Sciences, Dentistry, Physical Therapy, Veterinary Medicine, and Basic and Biological Sciences. The following abstracting and indexing services cover the Journal of Advanced Research: PubMed/Medline, Essential Science Indicators, Web of Science, Scopus, PubMed Central, PubMed, Science Citation Index Expanded, Directory of Open Access Journals (DOAJ), and INSPEC.
期刊最新文献
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