Thorase 缺乏症会导致小鼠大脑中 Aβ 积累和 tau 过度磷酸化

IF 13 1区医学 Q1 CLINICAL NEUROLOGY Alzheimer's & Dementia Pub Date : 2024-11-13 DOI:10.1002/alz.14329

Han Zhang, Menghua Cai, Fei Gao, Jia Yang, Chao Li, Jingyi Han, Yue Wang, Yi Xu, Yu Hu, Hui Chen, Wei He, Jianmin Zhang

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引用次数: 0

摘要

阿尔茨海默病（AD）患者大脑中的两大致病特征--淀粉样蛋白β（Aβ）积累和高磷酸化tau蛋白--的发病机理仍不清楚。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Thorase deficiency causes both Aβ accumulation and tau hyperphosphorylation in mouse brain

The pathogenesis of two major pathogenic characters—amyloid beta (Aβ) accumulation and hyperphosphorylated tau protein—in the brains of patients with Alzheimer's disease (AD) remains unclear.

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.