奶牛肝包虫病 FhSAMS 疫苗的安全性和免疫原性

IF 1.4 4区医学 Q4 IMMUNOLOGY Parasite Immunology Pub Date : 2024-11-01 DOI:10.1111/pim.13074

Kelvinson Fernandes Viana, Natânia do Carmo Sperandio, Felipe Berbari Neto, Dirlei Molinari Donatele, Adrieli Barboza de Souza, Angelo Gabriel Vidal Dos Santos, Açucena Veleh Rivas, Ema Carolina de Almeida Barcellos, Isabella Vilhena Freire Martins

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引用次数: 0

摘要

蝇蛆病是一种对牲畜和公共卫生都非常重要的寄生虫病，被世界卫生组织视为一种被忽视的疾病。疾病控制非常复杂，从经济、环境和健康角度来看，再感染使得使用治疗产品成为一种不可持续的方法。本研究的目的是评估一种用于奶牛的新型疫苗配方，其中含有与蒙大尼 763 AVG 和皂素佐剂（FhSAMS）相关的可溶性肝包虫病抗原。对该疫苗进行了两种方案的测试，一种是单剂，另一种是首剂 6 个月后的加强剂量。事实证明，FhSAMS 疫苗是安全的，没有副作用。此外，当使用 6 个月的加强剂量时，它还能产生更强的体液免疫反应，此外还能刺激产生更多的 IFN-ʏ，这表明它是一种 Th1 型免疫刺激。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Safety and Immunogenicity of an FhSAMS Vaccine Against Fasciola hepatica in Dairy Cattle.

Fasciolosis is a parasitosis of great importance for livestock, as well as for public health, as it is considered by the WHO as a neglected disease. Disease control is complex and reinfections make the use of therapeutic products an unsustainable method from an economic, environmental and health point of view. The aim of this study was to evaluate a new vaccine formulation for dairy cattle, containing soluble Fasciola hepatica antigens associated with Montanide 763 AVG and saponin adjuvants (FhSAMS). The vaccine was tested with two protocols, a single dose and a booster dose 6 months after the first dose. The FhSAMS vaccine proved to be safe, with no side effects. Furthermore, it was able to generate a more robust humoral immune response when a six-month booster dose was used, in addition to stimulating greater production of IFN-ʏ, indicating a Th1 profile immune stimulus.

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来源期刊

Parasite Immunology 医学-寄生虫学

CiteScore

4.70

自引率

4.50%

发文量

审稿时长

6-12 weeks

期刊介绍： Parasite Immunology is an international journal devoted to research on all aspects of parasite immunology in human and animal hosts. Emphasis has been placed on how hosts control parasites, and the immunopathological reactions which take place in the course of parasitic infections. The Journal welcomes original work on all parasites, particularly human parasitology, helminths, protozoa and ectoparasites.