[成纤维细胞生长因子家族的非典型激素]。

S A Gronskaia, N V Rusyaeva, Zh E Belaya, G A Melnichenko
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摘要

成纤维细胞生长因子(FGFs)是一组信号分子,因其能够促进成纤维细胞和其他各种细胞的生长和增殖而得名。通常情况下,成纤维细胞生长因子通过与其合成组织内的受体结合而在局部发挥作用。然而,该家族的某些成员,如 FGF 19、FGF 21 和 FGF 23,却与这种模式不同。合成后,这些 FGF 进入血液,通过与受体和相关辅助因子结合作用于远处的器官和组织,因此被归类为 FGF 家族中的非经典激素。FGF 的生物功能多种多样,取决于其信号传导途径中涉及的特定受体和辅助因子。例如,成纤维细胞生长因子 19 和成纤维细胞生长因子 21 在调节葡萄糖和脂质代谢方面发挥关键作用,而成纤维细胞生长因子 23 则主要影响磷代谢。本综述旨在巩固目前对 FGF 家族激素的认识,阐明其生物学影响,并探讨其作为治疗靶点的潜在应用。
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[Non-classical hormones from the fibroblast growth factor family].

Fibroblast growth factors (FGFs) are a group of signaling molecules named for their ability to promote the growth and proliferation of fibroblasts and various other cell types. Typically, FGFs exert their effects locally by binding to receptors within the tissues where they are synthesized. However, certain members of this family, such as FGF 19, FGF 21, and FGF 23, diverge from this pattern. Following synthesis, these FGFs enter the bloodstream and act on distant organs and tissues by binding to their receptors and associated cofactors, thereby classified as non-classical hormones within the FGF family.The biological functions of FGFs are diverse and contingent upon the specific receptors and cofactors involved in their signaling pathways. For instance, FGF 19 and FGF 21 play crucial roles in regulating glucose and lipid metabolism, whereas FGF 23 primarily influences phosphorus metabolism. Given their varied roles, FGFs present promising targets for therapeutic interventions and drug development.This review aims to consolidate current understanding of FGF family hormones, elucidating their biological impacts and exploring their potential applications as therapeutic targets.

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