Yuan Wang, Fang Xu, Yixuan Wang, Xinran Hu, Baofeng Zhao, Sen Lin* and Xifan Mei*,
{"title":"普鲁士蓝纳米结构共轭小檗碱通过抑制坏死改善类风湿性关节炎的炎症反应","authors":"Yuan Wang, Fang Xu, Yixuan Wang, Xinran Hu, Baofeng Zhao, Sen Lin* and Xifan Mei*, ","doi":"10.1021/acsanm.4c0446610.1021/acsanm.4c04466","DOIUrl":null,"url":null,"abstract":"<p >Rheumatoid arthritis has serious consequences for human health. Drugs can relieve the symptoms of some patients, but they exert significant toxic side effects. We loaded berberine into the Prussian blue nanostructure, synthesizing BRB-PB composites. It improves photothermal properties and exhibits potent anti-inflammatory and antioxidant effects. BRB-PB composites inhibited RIPK1/RIPK3/MLKL signaling pathway activation in RA synovial tissue, suggesting a unique molecular mechanism that reduces the occurrence of necroptosis and improves RA symptoms. Rapid metabolism and excellent biocompatibility of BRB-PB composites enhanced their safety and efficacy.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":null,"pages":null},"PeriodicalIF":5.3000,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Prussian Blue Nanostructure Conjugated Berberine Improves Inflammatory Response of Rheumatoid Arthritis by Suppressing Necroptosis\",\"authors\":\"Yuan Wang, Fang Xu, Yixuan Wang, Xinran Hu, Baofeng Zhao, Sen Lin* and Xifan Mei*, \",\"doi\":\"10.1021/acsanm.4c0446610.1021/acsanm.4c04466\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >Rheumatoid arthritis has serious consequences for human health. Drugs can relieve the symptoms of some patients, but they exert significant toxic side effects. We loaded berberine into the Prussian blue nanostructure, synthesizing BRB-PB composites. It improves photothermal properties and exhibits potent anti-inflammatory and antioxidant effects. BRB-PB composites inhibited RIPK1/RIPK3/MLKL signaling pathway activation in RA synovial tissue, suggesting a unique molecular mechanism that reduces the occurrence of necroptosis and improves RA symptoms. Rapid metabolism and excellent biocompatibility of BRB-PB composites enhanced their safety and efficacy.</p>\",\"PeriodicalId\":6,\"journal\":{\"name\":\"ACS Applied Nano Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":5.3000,\"publicationDate\":\"2024-10-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Nano Materials\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://pubs.acs.org/doi/10.1021/acsanm.4c04466\",\"RegionNum\":2,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MATERIALS SCIENCE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Nano Materials","FirstCategoryId":"88","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acsanm.4c04466","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
Prussian Blue Nanostructure Conjugated Berberine Improves Inflammatory Response of Rheumatoid Arthritis by Suppressing Necroptosis
Rheumatoid arthritis has serious consequences for human health. Drugs can relieve the symptoms of some patients, but they exert significant toxic side effects. We loaded berberine into the Prussian blue nanostructure, synthesizing BRB-PB composites. It improves photothermal properties and exhibits potent anti-inflammatory and antioxidant effects. BRB-PB composites inhibited RIPK1/RIPK3/MLKL signaling pathway activation in RA synovial tissue, suggesting a unique molecular mechanism that reduces the occurrence of necroptosis and improves RA symptoms. Rapid metabolism and excellent biocompatibility of BRB-PB composites enhanced their safety and efficacy.
期刊介绍：
ACS Applied Nano Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics and biology relevant to applications of nanomaterials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important applications of nanomaterials.
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