Mohammad Mujahid, Vijay Vara, Usman Arshad, Rama Krishna Gamidi, M. Muthukrishnan
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Cu-Catalyzed Multicomponent Reaction of Arylhydrazines with β-Ketoesters and TBN: One-Pot Access to N2-Aryl 1,2,3-Triazole-1-Oxides
We report a copper-catalyzed one-pot, multicomponent strategy for the convenient synthesis of N2-aryl 1,2,3-triazole-1-oxides using arylhydrazines, β-ketoesters, and tert-butyl nitrite. This mild and simple reaction proceeds in an atom-economic manner with broad substrate scope, affording a variety of N2-aryl 1,2,3-triazole-1-oxide derivatives. Other salient features of the reaction are good functional group tolerance, scalability, and product diversification.
期刊介绍：
The Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.
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