溶剂控制的 Rh(III)-Catalyzed Mono- and Dual Functionalization of Quinolyl Aldoximes with Diazo Compounds 重氮化合物催化喹啉基醛肟的单官能化和双官能化反应

IF 3.3 2区化学 Q1 CHEMISTRY, ORGANIC The Journal of Organic Chemistry Pub Date : 2024-11-14 DOI:10.1021/acs.joc.4c01896

Peng Zhang, Shan Xu, ShihaoZhi Wang, Xue-jing Zhang, Ming Yan

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引用次数: 0

摘要

以重氮化合物为单一偶联剂，展示了溶剂控制的 Rh(III)- 催化单-和双-C-H 键活化/碳迁移插入反应。反应在温和的条件下进行，产物收率良好甚至极佳。这些结果对于通过类羰基插入法实现 C（sp2）-H 键多米诺多重官能化的发展具有重要意义。

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Solvent-Controlled Rh(III)-Catalyzed Mono- and Dual Functionalization of Quinolyl Aldoximes with Diazo Compounds

A solvent-controlled Rh(III)-catalyzed mono- and dual-C–H bond activation/carbene migratory insertion with diazo compounds as a single coupling partner was demonstrated. The reaction proceeded under mild conditions, yielding products in good to excellent yields. These results are significant for the development of the domino multiple functionalization of C(sp²)–H bonds via a carbenoid insertion approach.

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来源期刊

The Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： The Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.