疫苗诱发免疫性血栓性血小板减少症的遗传易感性。

IF 5.1 2区医学 Q1 HEMATOLOGY British Journal of Haematology Pub Date : 2024-11-10 DOI:10.1111/bjh.19885

Donald M Arnold, Guillaume Paré, Ishac Nazy

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引用次数: 0

摘要

疫苗诱导的免疫性血栓性血小板减少症（VITT）是一种罕见的血栓前疾病，具有独特的克隆限制免疫学特征。Petito 和 Bury 等人的研究深入探讨了 HLA 多态性的作用以及 VITT 的内在易感性。评论Petito等人.人类白细胞抗原位点与疫苗诱导的免疫性血小板减少症的关系：血小板因子 4 衍生肽与 MHC-II 之间相互作用的潜在作用。Br J Haematol 2024 (Online ahead of print). doi: 10.1111/bjh.19838.

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Genetic predisposition to vaccine-induced immune thrombotic thrombocytopenia.

Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare prothrombotic disorder with a unique clonality-restricted immunological profile. The study by Petito and Bury et al. provides insight into the role of HLA polymorphisms and an inherent predisposition to VITT. Commentary on: Petito et al. Association of human leucocyte antigen loci with vaccine-induced immune thrombotic thrombocytopenia: Potential role of the interaction between platelet factor 4-derived peptides and MHC-II. Br J Haematol 2024 (Online ahead of print). doi: 10.1111/bjh.19838.

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来源期刊

British Journal of Haematology 医学-血液学

CiteScore

8.60

自引率

4.60%

发文量

565

审稿时长

1 months

期刊介绍： The British Journal of Haematology publishes original research papers in clinical, laboratory and experimental haematology. The Journal also features annotations, reviews, short reports, images in haematology and Letters to the Editor.