Anastasiia A Uspenskaia, Irina A Doroshenko, Kseniia A Popovicheva, Nazar V Shmychkov, Ekaterina V Pryakhina, Radik R Shafikov, Dmitrii A Skvortsov, Mikhail K Beklemishev, Olga V Zaborova, Tatiana A Podrugina, Aleksei E Machulkin, Elena K Beloglazkina
{"title":"带有炔基的五甲基氰基染料，可作为与靶向分子共轭的透视结构。","authors":"Anastasiia A Uspenskaia, Irina A Doroshenko, Kseniia A Popovicheva, Nazar V Shmychkov, Ekaterina V Pryakhina, Radik R Shafikov, Dmitrii A Skvortsov, Mikhail K Beklemishev, Olga V Zaborova, Tatiana A Podrugina, Aleksei E Machulkin, Elena K Beloglazkina","doi":"10.1016/j.bmcl.2024.130025","DOIUrl":null,"url":null,"abstract":"<p><p>We report a modified carbocyanine-based asymmetric fluorescent dye, suitable for the azide-alkyne cycloaddition reaction, that possesses promising photochemical properties (Φ<sub>fl</sub> = 0,49). As an example of usage of the new fluorophore, it was conjugated to a ligand targeting prostate-specific membrane antigen (PSMA), one of the widely utilized prostate cancer markers.</p>","PeriodicalId":256,"journal":{"name":"Bioorganic & Medicinal Chemistry Letters","volume":" ","pages":"130025"},"PeriodicalIF":2.5000,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Pentamethine cyanine dyes with alkynyl group as perspective structure for conjugation with targeting moiety.\",\"authors\":\"Anastasiia A Uspenskaia, Irina A Doroshenko, Kseniia A Popovicheva, Nazar V Shmychkov, Ekaterina V Pryakhina, Radik R Shafikov, Dmitrii A Skvortsov, Mikhail K Beklemishev, Olga V Zaborova, Tatiana A Podrugina, Aleksei E Machulkin, Elena K Beloglazkina\",\"doi\":\"10.1016/j.bmcl.2024.130025\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>We report a modified carbocyanine-based asymmetric fluorescent dye, suitable for the azide-alkyne cycloaddition reaction, that possesses promising photochemical properties (Φ<sub>fl</sub> = 0,49). As an example of usage of the new fluorophore, it was conjugated to a ligand targeting prostate-specific membrane antigen (PSMA), one of the widely utilized prostate cancer markers.</p>\",\"PeriodicalId\":256,\"journal\":{\"name\":\"Bioorganic & Medicinal Chemistry Letters\",\"volume\":\" \",\"pages\":\"130025\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2024-11-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bioorganic & Medicinal Chemistry Letters\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.bmcl.2024.130025\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioorganic & Medicinal Chemistry Letters","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.bmcl.2024.130025","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
Pentamethine cyanine dyes with alkynyl group as perspective structure for conjugation with targeting moiety.
We report a modified carbocyanine-based asymmetric fluorescent dye, suitable for the azide-alkyne cycloaddition reaction, that possesses promising photochemical properties (Φfl = 0,49). As an example of usage of the new fluorophore, it was conjugated to a ligand targeting prostate-specific membrane antigen (PSMA), one of the widely utilized prostate cancer markers.
期刊介绍：
Bioorganic & Medicinal Chemistry Letters presents preliminary experimental or theoretical research results of outstanding significance and timeliness on all aspects of science at the interface of chemistry and biology and on major advances in drug design and development. The journal publishes articles in the form of communications reporting experimental or theoretical results of special interest, and strives to provide maximum dissemination to a large, international audience.
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