尼泊尔患者服用大剂量氨氯地平诱发牙龈增生:病例报告。

IF 1.7 Q2 MEDICINE, GENERAL & INTERNAL Annals of Medicine and Surgery Pub Date : 2024-09-18 eCollection Date: 2024-11-01 DOI:10.1097/MS9.0000000000002540
Basanta Chaulagain, Omkar Jha, Sumina Mainali, Prakriti Sharma
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引用次数: 0

摘要

简介和重要性:氨氯地平是第三代钙通道阻滞剂,用于治疗高血压。氨氯地平的副作用之一是牙龈增生,主要发生在高剂量(10 毫克)时。氨氯地平剂量较低(5 毫克)或短期用药引起牙龈增生的病例很少:一名 51 岁的男性高血压患者因牙龈肿胀和刷牙时牙龈出血而就医。他服用 5 毫克氨氯地平 12 个月,最近 2 个月增至 10 毫克。病史和体格检查结果与氨氯地平诱发的牙龈增生一致。临床讨论和结论:本病例凸显了在尼泊尔等低收入国家使用氨氯地平治疗高血压时,在经济因素和潜在副作用之间取得平衡所面临的挑战。由于氨氯地平可以免费或以最低的成本获得,因此通常被作为一线治疗药物。然而,受经济限制和药物价格的影响,将剂量增加到每天 10 毫克的决定增加了牙龈增生的风险。本病例强调了医生在处方较高剂量的氨氯地平时注意潜在不良反应的重要性,并强调了在资源有限的环境中管理高血压需要持续保持警觉。
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Amlodipine-induced gingival hyperplasia in a Nepalese patient experiencing high dosages: a case report.

Introduction and importance: Amlodipine is a third-generation calcium channel blocker used in the treatment of hypertension. One of the side effects associated with amlodipine is gingival hyperplasia mostly occurring at a higher dose (10 mg). There are very few cases of gingival hyperplasia associated with amlodipine at a lower dose (5 mg) or short-term administration.

Case presentation: A 51-year-old male patient with diagnosed hypertension sought medical attention for gingival swelling and bleeding from the gums while brushing. He had been under amlodipine 5 mg for 12 months, which was increased to 10 mg for the last 2 months. The history and physical examination were consistent with amlodipine-induced gingival hyperplasia. The first line of treatment consisted of discontinuation of amlodipine and substitution with another class of anti-hypertensive.

Clinical discussion and conclusion: The presented case highlights the challenge of balancing economic considerations with potential side effects in the use of amlodipine for hypertension in low-income countries like Nepal. Given its availability at no cost or minimal expense, amlodipine is often initiated as a first-line therapy. However, the decision to increase the dosage to 10 mg/day, influenced by economic constraints and the drug's affordability, raises the risk of gingival hyperplasia. This case emphasizes the importance of physicians being mindful of potential adverse effects when prescribing higher doses of amlodipine and underscores the need for continued vigilance in managing hypertension in resource-limited settings.

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Annals of Medicine and Surgery
Annals of Medicine and Surgery MEDICINE, GENERAL & INTERNAL-
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5.90%
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