Assessing the Performance of ChatGPT and Bard/Gemini Against Radiologists for PI-RADS Classification Based on Prostate Multiparametric MRI Text Reports.

Objectives: Large language models (LLMs) have shown potential for clinical applications. This study assesses their ability to assign PI-RADS categories based on clinical text reports.

Methods: One hundred consecutive biopsy-naïve patients' multiparametric prostate MRI reports were independently classified by two uroradiologists, GPT-3.5, GPT-4, Bard, and Gemini. Original report classifications were considered definitive.

Results: Out of 100 MRIs, 52 were originally reported as PI-RADS 1-2, 9 PI-RADS 3, 19 PI-RADS 4, and 20 PI-RADS 5. Radiologists demonstrated 95% and 90% accuracy, while GPT-3.5 and Bard both achieved 67%. Accuracy of the updated versions of LLMs increased to 83% (GTP-4) and 79% (Gemini), respectively. In low suspicion studies (PI-RADS 1-2), Bard and Gemini (F1: 0.94, 0.98, respectively) outperformed GPT-3.5 and GTP-4 (F1:0.77, 0.94, respectively), whereas for high probability MRIs (PI-RADS 4-5), GPT-3.5 and GTP-4 (F1: 0.95, 0.98, respectively) outperformed Bard and Gemini (F1: 0.71, 0.87, respectively). Bard assigned a non-existent PI-RADS 6 "hallucination" for two patients. Inter-reader agreements (Κ) between the original reports and the senior radiologist, junior radiologist, GPT-3.5, GTP-4, BARD, and Gemini were 0.93, 0.84, 0.65, 0.86, 0.57, and 0.81, respectively.

Conclusions: Radiologists demonstrated high accuracy in PI-RADS classification based on text reports, while GPT-3.5 and Bard exhibited poor performance. GTP-4 and Gemini demonstrated improved performance compared to their predecessors.

Advances in knowledge: This study highlights the limitations of LLMs in accurately classifying PI-RADS categories from clinical text reports. While the performance of LLMs has improved with newer versions, caution is warranted before integrating such technologies into clinical practice.