选择性腹腔镜乙状结肠切除术可降低无并发症复发性憩室炎患者的 IL-6 血清水平

IF 0.8 Q4 SURGERY Chirurgia Pub Date : 2024-10-01 DOI:10.21614/chirurgia.3047
Giulio Mari, Richard Sassun, Simone Ciciriello, Francesca Roufael, Dario Maggioni, Gaia Santambrogio, Roberto Delpini, Eugenio Cocozza, Pietro Calcagno, Giovanni Ferrari, Giorgia Rodda, Antonino Spinelli, Marko Markovic, Andrea Costanzi, Giacomo Calini, Roberto Cirocchi, Abe Fingerhut
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引用次数: 0

摘要

导言:虽然从临床角度来看,复发性憩室炎似乎是一种慢性复发性疾病,但目前还没有足够的数据显示炎症标志物可用于监测复发性憩室炎的静止期。我们的假设是,在憩室炎的临床静止期,血清炎症标志物可能会升高,而在对无并发症的复发性憩室炎进行选择性腹腔镜乙状结肠切除术后,血清炎症标志物会下降。我们还认为,手术后 IL-6 水平的下降可能与生活质量的改善有关。材料和方法:这项流行病学研究旨在评估 30 名接受选择性腹腔镜乙状结肠切除术治疗无并发症复发性憩室炎的患者术前和术后 6 个月的 IL-6 血清水平和生活质量。结果显示术前 IL-6 平均水平为 9.5 Ã+- 9.2 pg/ml(范围 0-5),术后 6 个月 IL-6 平均水平为 4.5 +- 3.5。(p=0.0085).术前通过 GIQLI 问卷测量的 QoL 为 98 +- 11.3,术后显著提高至 112 +- 9.8 (p=0.043)。结论:我们发现选择性腹腔镜乙状结肠切除术后血清IL-6降低,这可能是由于手术切除了无并发症复发性憩室炎患者的炎症源。同样,GIQLI问卷调查显示,术后患者的生活质量明显改善。
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Elective Laparoscopic Sigmoidectomy Reduces IL-6 Serum Levels in Uncomplicated Recurrent Diverticulitis.

Introduction: Although recurrent diverticulitis appears to be a chronic relapsing disease from a clinical standpoint, there are no sufficient data about inflammatory markers that allow monitoring recurrent diverticulitis in the quiescent phase. Our hypothesis is that serum inflammatory markers may be increased during clinical quiescent phases of diverticulitis and will drop after elective laparoscopic sigmoidectomy for uncomplicated recurrent diverticulitis. We also believe that a drop in IL-6 levels across surgery could be related to an improved quality of life. Material and Methods: This epidemiological study aims to evaluate IL-6 serum levels and quality of life preoperatively and 6 months after surgery in 30 patients undergoing elective laparoscopic sigmoidectomy for uncomplicated recurrent diverticulitis. Results: The mean preoperative IL-6 level was 9.5 Ã+- 9.2 pg/ml (range 0-5), while at six months after surgery the mean IL-6 was 4.5 +- 3.5. (p=0.0085). Preoperative QoL measured with the GIQLI questionnaire was 98 +- 11.3 and raised significantly after surgery to 112 +- 9.8 (p=0.043). Conclusions: We found a serum IL-6 reduction after elective laparoscopic sigmoidectomy that can be attributed to the surgical removal of the source of inflammation in patients suffering from uncomplicated recurrent diverticulitis. Similarly, the GIQLI questionnaire showed a significantly improved QoL after surgery.

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来源期刊
Chirurgia
Chirurgia Medicine-Surgery
CiteScore
1.00
自引率
0.00%
发文量
75
审稿时长
4-8 weeks
期刊介绍: Chirurgia is a bimonthly journal. In Chirurgia, original papers in the area of general surgery which neither appeared, nor were sent for publication in other periodicals, can be published. You can send original articles, new surgical techniques, or comprehensive general reports on surgical topics, clinical case presentations and, depending on publication space, - reviews of some articles of general interest to surgeons from other publications. Chirurgia is also a place for sharing information about the activity of various branches of the Romanian Society of Surgery, information on Congresses and Symposiums organized by the Romanian Society of Surgery and participation notes in other scientific meetings. Letters to the editor: Letters commenting on papers published in Chirurgia are welcomed. They should contain substantive ideas and commentaries supported by appropriate data, and should not exceed 2 pages. Please submit these letters to the editor through our online system.
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