中性粒细胞与淋巴细胞比率可预测糖尿病患者的心血管预后:系统回顾与元分析》。

IF 2 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Cardiology in Review Pub Date : 2024-11-12 DOI:10.1097/CRD.0000000000000820
Ghazal Ghasempour Dabaghi, Mehrdad Rabiee Rad, Mohammadreza Mortaheb, Bahar Darouei, Reza Amani-Beni, Sadegh Mazaheri-Tehrani, Mahshad Izadan, Ali Touhidi
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引用次数: 0

摘要

中性粒细胞与淋巴细胞比值(NLR)被认为是急性炎症和不同疾病预后的潜在生物标志物。在此,我们对评估 NLR 与糖尿病患者心血管预后相关性的研究进行了荟萃分析。我们检索了从开始到 2024 年 4 月 6 日的 PubMed、Scopus 和 Web of Science 数据库,以纳入符合标准的论文。研究结果包括全因死亡率、心血管死亡率、主要不良心血管事件、心肌梗死和中风。报告了汇总风险比 (RR) 和相应的 95% 置信区间 (CI)。使用 StataMP 14.0 进行了 Meta 分析。共纳入 15 项研究,涉及 407 512 名参与者。Meta 分析表明,分类和连续 NLR 均与全因死亡风险增加有关(RR = 1.68; 95% CI, 1.49-1.88; P < 0.001 和 RR = 1.03; 95% CI, 1.03-1.P<0.001)和心血管死亡率(RR=2.04;95% CI,1.58-2.63;P<0.001 和 RR=1.25;95% CI,1.19-1.32;P<0.001)。然而,NLR与糖尿病患者发生主要不良心血管事件、心肌梗死和中风的风险无关。亚组分析表明,样本大小是造成不同研究间异质性的主要原因。研究结果表明,NLR 是糖尿病患者死亡结果的预后标志物,为临床医生提供了一个无创、随时可用的风险评估和患者管理指标。
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The Neutrophil-to-Lymphocyte Ratio Predicts Cardiovascular Outcomes in Patients With Diabetes: A Systematic Review and Meta-Analysis.

The neutrophil-to-lymphocyte ratio (NLR) has been found as a potential biomarker for acute inflammation and the prognosis of different diseases. Here, we provided a meta-analysis of studies evaluating the association of NLR with cardiovascular outcomes among patients with diabetes. We searched PubMed, Scopus, and Web of Science databases from inception to April 06, 2024, to include papers based on eligible criteria. The outcomes of interest were all-cause mortality, cardiovascular mortality, major adverse cardiovascular events, myocardial infarction, and stroke. The pooled risk ratio (RR) and corresponding 95% confidence intervals (CI) were reported. Meta-analysis was performed using StataMP 14.0. A total of 15 studies involving 407,512 participants were included. Meta-analysis revealed that both categorical and continuous NLRs are linked to increased risk of all-cause mortality (RR = 1.68; 95% CI, 1.49-1.88; P < 0.001 and RR = 1.03; 95% CI, 1.03-1.03; P < 0.001, respectively) and cardiovascular mortality (RR = 2.04; 95% CI, 1.58-2.63; P < 0.001 and RR = 1.25; 95% CI, 1.19-1.32; P < 0.001, respectively) in patients with diabetes. However, NLR was not associated with the risk of major adverse cardiovascular events, myocardial infarction, and stroke in patients with diabetes. Subgroup analysis revealed sample size as the main source of the heterogeneity found between studies. The findings suggest NLR as a prognostic marker for mortality outcomes in patients with diabetes, providing clinicians with a noninvasive and readily available indicator for risk assessment and patient management.

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来源期刊
Cardiology in Review
Cardiology in Review CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
4.60
自引率
0.00%
发文量
76
审稿时长
>12 weeks
期刊介绍: The mission of Cardiology in Review is to publish reviews on topics of current interest in cardiology that will foster increased understanding of the pathogenesis, diagnosis, clinical course, prevention, and treatment of cardiovascular disorders. Articles of the highest quality are written by authorities in the field and published promptly in a readable format with visual appeal
期刊最新文献
The Neutrophil-to-Lymphocyte Ratio Predicts Cardiovascular Outcomes in Patients With Diabetes: A Systematic Review and Meta-Analysis.
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