氨死亡：增强癌症免疫疗法的潜在新策略。

IF 5 3区医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Cancer gene therapy Pub Date : 2024-11-11 DOI:10.1038/s41417-024-00851-y

Zhi Li, Junyi Lin, Peihao Yin

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引用次数: 0

摘要

CD8 + T细胞在发挥其抗肿瘤作用后的低存活率降低了免疫治疗的效果。最近的研究表明，氨由谷氨酰胺代谢产生，在效应CD8 + T细胞中积累并触发其凋亡。这些发现从代谢的角度对效应t细胞死亡提供了全面的机制理解，为改善t细胞介导的抗癌治疗提供了新的机会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Ammonia death: a novel potential strategy to augment immunotherapy in cancer

The efficacy of immunotherapy is diminished by the low survival rate of effector CD8 + T cells after they have exerted their antitumor effects. Recent studies indicate that ammonia, generated from glutamine metabolism, accumulates in effector CD8 + T cells and triggers their apoptosis. These findings offer a comprehensive mechanistic understanding of effector T-cell mortality from a metabolic viewpoint, presenting novel opportunities for improving T-cell-mediated anticancer treatments.

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来源期刊

Cancer gene therapy 医学-生物工程与应用微生物

CiteScore

10.20

自引率

0.00%

发文量

150

审稿时长

4-8 weeks

期刊介绍： Cancer Gene Therapy is the essential gene and cellular therapy resource for cancer researchers and clinicians, keeping readers up to date with the latest developments in gene and cellular therapies for cancer. The journal publishes original laboratory and clinical research papers, case reports and review articles. Publication topics include RNAi approaches, drug resistance, hematopoietic progenitor cell gene transfer, cancer stem cells, cellular therapies, homologous recombination, ribozyme technology, antisense technology, tumor immunotherapy and tumor suppressors, translational research, cancer therapy, gene delivery systems (viral and non-viral), anti-gene therapy (antisense, siRNA & ribozymes), apoptosis; mechanisms and therapies, vaccine development, immunology and immunotherapy, DNA synthesis and repair. Cancer Gene Therapy publishes the results of laboratory investigations, preclinical studies, and clinical trials in the field of gene transfer/gene therapy and cellular therapies as applied to cancer research. Types of articles published include original research articles; case reports; brief communications; review articles in the main fields of drug resistance/sensitivity, gene therapy, cellular therapy, tumor suppressor and anti-oncogene therapy, cytokine/tumor immunotherapy, etc.; industry perspectives; and letters to the editor.