药用植物龙胆中的抗炎萃取物

IF 2.3 3区化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Chemistry & Biodiversity Pub Date : 2024-11-11 DOI:10.1002/cbdv.202402653

Huan Liu, Hui-Zhen Cheng, Xiao-Yu Qi, Yu-Zhou Fan, Zhong-Zhu Yuan, Yuan-Liang Xu, Yan Liu, Kai Guo, Sheng-Hong Li

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引用次数: 0

摘要

从药用植物龙胆（Gentianopsis barbata）的全株中分离出了五种新的仲呋喃糖苷类化合物--龙胆肽 A-E（1-5）以及两种已知的类似物（6 和 7）。通过对大量光谱分析（一维和二维核磁共振以及 HRMS）和量子化学计算的比较，阐明了它们的结构。龙胆草素 A（1）和 B（2）代表了两种不同寻常的三卤代海鞘糖苷骨架。通过抑制 LPS 诱导的巨噬细胞 RAW264.7 中细胞因子 TNF-α 和 IL-6 的分泌，评估了这些分离物的抗炎活性。化合物 3 和 7 对 IL-6 的分泌具有显著的抑制活性，IC50 值分别为 10.22 和 13.30 μM。

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Anti-Inflammatory Secoiridoids from the Medicinal Herb Gentianopsis barbata.

Five new secoiridoids, gentianopsins A-E (1-5), along with two known analogues (6 and 7) were isolated from the whole plants of the medicinal herb Gentianopsis barbata. Their structures were elucidated by a comparison of extensive spectroscopic analysis (1D and 2D NMR, and HRMS) and quantum chemical calculations. Gentianopsins A (1) and B (2) represented two unusual skeletons of trihomo-secoiridoids. Anti-inflammatory activity of these isolates was evaluated via suppressing the secretion of cytokines TNF-α and IL-6 in LPS-induced macrophages RAW264.7. Significant inhibitory activity was observed for compounds 3 and 7 on IL-6 secretion with IC50 values of 10.22 and 13.30 μM, respectively.

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来源期刊

Chemistry & Biodiversity 环境科学-化学综合

CiteScore

3.40

自引率

10.30%

发文量

475

审稿时长

2.6 months

期刊介绍： Chemistry & Biodiversity serves as a high-quality publishing forum covering a wide range of biorelevant topics for a truly international audience. This journal publishes both field-specific and interdisciplinary contributions on all aspects of biologically relevant chemistry research in the form of full-length original papers, short communications, invited reviews, and commentaries. It covers all research fields straddling the border between the chemical and biological sciences, with the ultimate goal of broadening our understanding of how nature works at a molecular level. Since 2017, Chemistry & Biodiversity is published in an online-only format.