磷代谢：对矿物质代谢紊乱的影响。

IF 3.7 3区医学 Q2 Medicine Endocrine Pub Date : 2024-11-11 DOI:10.1007/s12020-024-04092-9

Maisa Monseff Rodrigues da Silva, John P Bilezikian, Francisco J A de Paula

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引用次数: 0

摘要

调控分子通常协同工作，以确保荷尔蒙系统的有效运作。例如，生殖生物学中的 LH 和 FSH，葡萄糖代谢中的胰岛素和胰高血糖素。同样，钙和磷也是骨骼平衡的重要调节剂。在血液循环中，这些分子受 PTH、1,25（OHD）和 FGF23 的控制。反过来，这些激素又依赖于它们之间复杂的相互作用。例如，钙代谢的改变会影响磷平衡，原发性甲状旁腺功能亢进症（PHPT）就是如此。磷代谢异常对钙稳态的影响还没有得到很好的认识。在这篇综述中，我们将关注磷代谢异常对钙代谢的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Phosphate metabolism: its impact on disorders of mineral metabolism.

Regulatory molecules typically work cooperatively to ensure the efficient functioning of hormonal systems. Examples include LH and FSH in reproductive biology, insulin and glucagon in glucose metabolism. Similarly, calcium and phosphorus are important regulators of skeletal homeostasis. In the circulation, these molecules are under the control of PTH, 1,25(OHD), and FGF23. In turn, these hormones depend upon a mutual and complex interplay among themselves. For example, alterations in calcium metabolism influence phosphorus homeostasis, as occurs in primary hyperparathyroidism (PHPT). Not as well recognized is the influence that abnormalities in phosphorus metabolism can have on calcium homeostasis. In this review, we call attention to the impact that abnormalities in phosphorus can have on calcium metabolism.

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来源期刊

Endocrine 医学-内分泌学与代谢

CiteScore

6.40

自引率

5.40%

发文量

期刊介绍： Well-established as a major journal in today’s rapidly advancing experimental and clinical research areas, Endocrine publishes original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical research in all the different fields of endocrinology and metabolism. Articles will be accepted based on peer-reviews, priority, and editorial decision. Invited reviews, mini-reviews and viewpoints on relevant pathophysiological and clinical topics, as well as Editorials on articles appearing in the Journal, are published. Unsolicited Editorials will be evaluated by the editorial team. Outcomes of scientific meetings, as well as guidelines and position statements, may be submitted. The Journal also considers special feature articles in the field of endocrine genetics and epigenetics, as well as articles devoted to novel methods and techniques in endocrinology. Endocrine covers controversial, clinical endocrine issues. Meta-analyses on endocrine and metabolic topics are also accepted. Descriptions of single clinical cases and/or small patients studies are not published unless of exceptional interest. However, reports of novel imaging studies and endocrine side effects in single patients may be considered. Research letters and letters to the editor related or unrelated to recently published articles can be submitted. Endocrine covers leading topics in endocrinology such as neuroendocrinology, pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, Type 1 and Type 2 diabetes, hormones of male and female reproduction, adrenal diseases pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.