评估利桑珠单抗治疗中重度溃疡性结肠炎的效果。

IF 3.6 3区医学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Expert Opinion on Biological Therapy Pub Date : 2024-11-13 DOI:10.1080/14712598.2024.2428311

Amanda M Johnson, Edward V Loftus

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引用次数: 0

摘要

简介利桑珠单抗（Risankizumab，RZB）是一种重组 IgG1 人源化单克隆抗体，通过与 p19 亚基的高亲和力结合，选择性地抑制白细胞介素（IL）-23。RZB 于 2022 年获准用于治疗克罗恩病（CD），并于 2024 年 6 月获得美国监管机构批准用于治疗溃疡性结肠炎（UC）：我们将研究目前可用的 UC 治疗方法，概述 IL-23 通路，讨论 RZB 用于 UC 的现有试验数据，并就 RZB 如何融入当前的 UC 治疗范式以及该领域的未来发展方向发表评论：RZB似乎是诱导和维持治疗无效和难治性UC患者病情缓解的有效药物，而且具有良好的安全性。选择性阻断IL-23与联合抑制IL-12/23相比，在治疗CD和银屑病等其他疾病方面具有潜在的疗效优势。

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An evaluation of risankizumab for the treatment of moderate-to-severe ulcerative colitis.

Introduction: Risankizumab (RZB) is a recombinant IgG₁ humanized monoclonal antibody which selectively inhibits interleukin (IL)-23 though high-affinity binding of the p19 subunit. RZB was approved for use in Crohn's disease (CD) in 2022 and received regulatory approval for ulcerative colitis (UC) in the United States in June 2024.

Areas covered: We will examine currently available therapies for UC, provide an overview of the IL-23 pathway, discuss available trial data for RZB in UC, and comment on how RZB may fit into the current UC treatment paradigm and future directions in the field.

Expert opinion: RZB appears to be an effective agent for inducing and maintaining remission in patients with both treatment-naïve and refractory UC, with a favorable safety profile. The selective blockade of IL-23 has demonstrated potential advantages in efficacy over combined IL-12/23 inhibition for other disease states like CD and psoriasis, although where it will be positioned amidst other clinically available advanced therapies in UC requires further study.

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来源期刊

Expert Opinion on Biological Therapy 医学-生物工程与应用微生物

CiteScore

8.60

自引率

0.00%

发文量

审稿时长

3-8 weeks

期刊介绍： Expert Opinion on Biological Therapy (1471-2598; 1744-7682) is a MEDLINE-indexed, international journal publishing peer-reviewed research across all aspects of biological therapy. Each article is structured to incorporate the author’s own expert opinion on the impact of the topic on research and clinical practice and the scope for future development. The audience consists of scientists and managers in the healthcare and biopharmaceutical industries and others closely involved in the development and application of biological therapies for the treatment of human disease. The journal welcomes: Reviews covering therapeutic antibodies and vaccines, peptides and proteins, gene therapies and gene transfer technologies, cell-based therapies and regenerative medicine Drug evaluations reviewing the clinical data on a particular biological agent Original research papers reporting the results of clinical investigations on biological agents and biotherapeutic-based studies with a strong link to clinical practice Comprehensive coverage in each review is complemented by the unique Expert Collection format and includes the following sections: Expert Opinion – a personal view of the data presented in the article, a discussion on the developments that are likely to be important in the future, and the avenues of research likely to become exciting as further studies yield more detailed results; Article Highlights – an executive summary of the author’s most critical points.