全膝关节置换术中胫骨平台骨囊肿残留骨缺损不同技术的生物力学分析。

IF 4.3 3区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Frontiers in Bioengineering and Biotechnology Pub Date : 2024-10-30 eCollection Date: 2024-01-01 DOI:10.3389/fbioe.2024.1498882
Dehua Liu, Zhuang Miao, Wenfei Zhang, Chuanwen Liu, Longzhuo Du, Yuanlong Zhu, Yange Luo, Weibo Zheng, Jianli Zhou, Peilai Liu, Xuezhou Li, Ming Li
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引用次数: 0

摘要

背景:在接受全膝关节置换术(TKA)的胫骨平台骨囊肿患者中,胫骨平台切除术后通常会出现骨缺损。目前解决这些缺损的策略包括骨移植、骨水泥填充和骨水泥-螺钉技术。然而,对于实现最佳手术效果的最佳方法仍未达成共识。本研究旨在从生物力学角度评估 TKA 中胫骨平台骨囊肿修复后残留骨缺损的最有效修复方法:方法:将胫骨平台骨缺损的治疗方案分为四类:不治疗、松质骨填充、骨水泥填充和骨水泥-螺钉技术。采用有限元分析(FEA)评估各治疗组模型的应力分布和位移。此外,还使用静态压缩机械测试来评估各组模型的位移情况:有限元分析结果表明,采用骨水泥-螺钉技术修复胫骨平台骨缺损时,假体和假体下方骨水泥的最大应力最小,而松质骨的最大应力最大。同时,每个组件的位移也最小。生物力学测试结果进一步证明,使用骨水泥螺丝钉技术治疗胫骨平台骨缺损时,模型的位移量最小:结论:使用骨水泥-螺钉技术治疗 TKA 中因骨囊肿造成的胫骨残余骨缺损具有最佳的生物力学优势。
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Biomechanical analysis of different techniques for residual bone defect from tibial plateau bone cyst in total knee arthroplasty.

Background: In patients with tibial plateau bone cysts undergoing total knee arthroplasty (TKA), bone defects commonly occur following tibial plateau resection. Current strategies for addressing these defects include bone grafting, bone cement filling, and the cement-screw technique. However, there remains no consensus on the optimal approach to achieve the best surgical outcomes. This study aims to evaluate the most effective repair method for residual bone defects following tibial plateau bone cyst repair during TKA from a biomechanical perspective.

Methods: The treatment options for tibial plateau bone defects were classified into four categories: no treatment, cancellous bone filling, bone cement filling, and the cement-screw technique. Finite-element analysis (FEA) was employed to evaluate stress distribution and displacement across the models for each treatment group. In addition, static compression mechanical tests were used to assess the displacement of the models within each group.

Results: FEA results indicate that when employing the cement-screw technique to repair tibial plateau bone defects, the maximum stress on the prosthesis and the cement below the prosthesis is minimized, while the maximum stress on the cancellous bone is maximized. And the displacement of each component is minimized. Biomechanical tests results further demonstrate that the displacement of the model is minimized when utilizing the cement-screw technique for tibial plateau bone defects.

Conclusion: Using cement-screw technique in treating residual tibial bone defects due to bone cysts in TKA offers optimal biomechanical advantages.

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来源期刊
Frontiers in Bioengineering and Biotechnology
Frontiers in Bioengineering and Biotechnology Chemical Engineering-Bioengineering
CiteScore
8.30
自引率
5.30%
发文量
2270
审稿时长
12 weeks
期刊介绍: The translation of new discoveries in medicine to clinical routine has never been easy. During the second half of the last century, thanks to the progress in chemistry, biochemistry and pharmacology, we have seen the development and the application of a large number of drugs and devices aimed at the treatment of symptoms, blocking unwanted pathways and, in the case of infectious diseases, fighting the micro-organisms responsible. However, we are facing, today, a dramatic change in the therapeutic approach to pathologies and diseases. Indeed, the challenge of the present and the next decade is to fully restore the physiological status of the diseased organism and to completely regenerate tissue and organs when they are so seriously affected that treatments cannot be limited to the repression of symptoms or to the repair of damage. This is being made possible thanks to the major developments made in basic cell and molecular biology, including stem cell science, growth factor delivery, gene isolation and transfection, the advances in bioengineering and nanotechnology, including development of new biomaterials, biofabrication technologies and use of bioreactors, and the big improvements in diagnostic tools and imaging of cells, tissues and organs. In today`s world, an enhancement of communication between multidisciplinary experts, together with the promotion of joint projects and close collaborations among scientists, engineers, industry people, regulatory agencies and physicians are absolute requirements for the success of any attempt to develop and clinically apply a new biological therapy or an innovative device involving the collective use of biomaterials, cells and/or bioactive molecules. “Frontiers in Bioengineering and Biotechnology” aspires to be a forum for all people involved in the process by bridging the gap too often existing between a discovery in the basic sciences and its clinical application.
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