小儿踝关节骨折的治疗:生物可降解聚乳酸(PLGA)植入物与传统金属螺钉的比较。

IF 2.1 3区 医学 Q2 PEDIATRICS Frontiers in Pediatrics Pub Date : 2024-10-30 eCollection Date: 2024-01-01 DOI:10.3389/fped.2024.1410750
Hermann Nudelman, Aba Lőrincz, Anna Gabriella Lamberti, Marcell Varga, Tamás Kassai, Gergő Józsa
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引用次数: 0

摘要

简介在现代临床实践中,生物可降解植入物的重要性日益凸显。本研究旨在评估与金属螺钉相比,使用可吸收植入物治疗踝关节骨折的效果和结果。这些植入物由聚 l-乳酸-聚乙二醇酸(PLGA)制成,但市场上也有其他几种材料可供选择:在一项回顾性研究中,共观察了 128 例胫骨远端骨折患者,其骨折类型从 Salter-Harris II 到 IV 不等。在可吸收组中,患者接受了植入物治疗(n = 76)。金属组包括使用钛或钢螺钉治疗的患者(n = 52)。术后肢体石膏固定 6 周,再使用 6-8 周。对患者进行了 12-30 个月的随访和相应的评估。作者从年龄、性别、开放或闭合修复、损伤机制、住院时间、骨折类型、恢复时间和并发症等几个方面进行了研究:结果:在年龄、骨折类型、受伤侧和石膏使用时间等人口统计学特征方面,各组之间没有明显差异(所有情况下,P>0.05)。在 PLGA 组的 76 名患者中,只有两人出现了并发症,因此进行了再次手术。其余患者均痊愈,未出现并发症或骨折。使用金属螺钉治疗的患者(52 人)中,2 人出现轻微并发症,4 人出现严重并发症,需要再次手术:讨论:在儿科病例中,PLGA植入物治疗踝关节骨折效果极佳。讨论:在小儿病例中,PLGA 植入物在治疗踝关节骨折方面效果极佳。因此,PLGA植入物可减轻患者和医护人员的负担,同时降低并发症的风险,如感染或全身麻醉引起的问题。
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Management of pediatric ankle fractures: comparison of biodegradable PLGA implants with traditional metal screws.

Introduction: The relevance of biodegradable implants has gained more importance in modern clinical practice. The study aimed to evaluate the effects and outcomes of ankle fracture treatment with absorbable implants compared to metal screws. These implants are made from poly l-lactic-co-glycolic acid (PLGA), however, there are several other materials available on the market.

Methods: In a retrospective review, a total of 128 patients were under observation, with distal tibial fracture types ranging from Salter-Harris II-IV. In the absorbable group, patients were treated with the implants (n = 76). The metal group included patients treated with titanium or steel screws (n = 52). The extremities were placed in a cast for six weeks after surgery and were utilized for another 6-8 weeks. Patients were followed up for 12-30 months and were evaluated accordingly. The authors examined several aspects such as age, gender, open or closed repair, mechanism of injury, length of hospitalization, type of fracture, time of recovery, and complications.

Results: There were no statistically significant differences between the groups regarding demographic qualities, such as age, type of fracture, side of injury, and length of cast application (p > 0.05 in all cases). Out of 76 patients in the PLGA group, only two presented with complications, so reoperation took place. The rest healed without complications or refractures. Two of those treated with metal screws (n = 52) had minor, and four had major complications with reoperation.

Discussion: In pediatric cases, PLGA implants may present excellent results for treating ankle fractures. They do not disturb the growth plate and do not require reoperation. For this reason, they reduce the burden on the patient and the healthcare provider while simultaneously decreasing the risk of complications, such as infections or problems due to general anesthesia.

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来源期刊
Frontiers in Pediatrics
Frontiers in Pediatrics Medicine-Pediatrics, Perinatology and Child Health
CiteScore
3.60
自引率
7.70%
发文量
2132
审稿时长
14 weeks
期刊介绍: Frontiers in Pediatrics (Impact Factor 2.33) publishes rigorously peer-reviewed research broadly across the field, from basic to clinical research that meets ongoing challenges in pediatric patient care and child health. Field Chief Editors Arjan Te Pas at Leiden University and Michael L. Moritz at the Children''s Hospital of Pittsburgh are supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. Frontiers in Pediatrics also features Research Topics, Frontiers special theme-focused issues managed by Guest Associate Editors, addressing important areas in pediatrics. In this fashion, Frontiers serves as an outlet to publish the broadest aspects of pediatrics in both basic and clinical research, including high-quality reviews, case reports, editorials and commentaries related to all aspects of pediatrics.
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