黄曲霉毒素B1与环吡唑酸毒性的相互作用。

Molecular toxicology Pub Date : 1987-01-01
I E Yates, R J Cole, J L Giles, J W Dorner
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引用次数: 0

摘要

通过监测真菌毒素环吡唑酸和黄曲霉毒素B1对海洋磷光细菌ncmb844的发光影响,分析了它们单独和联合使用的毒性。遗传毒性分析与该生物体的暗突变体,其恢复到生物发光条件是由化合物攻击鸟嘌呤位点在脱氧核糖核酸刺激。在本试验中,与黄曲霉毒素B1不同的是,当两种真菌毒素联合检测时,环吡唑酸不会增强环吡唑酸。在一个单独的检测系统中,用磷磷P.菌株NRRLB-1177的生物发光减弱来评估细胞毒性。环吡唑酸比黄曲霉毒素B1具有更强的细胞毒性,并且细胞毒性所需的环吡唑酸浓度随着时间的推移而降低,而黄曲霉毒素B1的细胞毒性表达在大多数试验条件下不随时间发生显著变化。黄曲霉毒素B1和环吡唑酸作为剂量对的测定表明,这些真菌毒素通过独立的作用方式引起它们的作用。
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Interaction of aflatoxin B1 and cyclopiazonic acid toxicities.

Toxic properties of the mycotoxins cyclopiazonic acid and aflatoxin B1 have been analyzed separately and in combination by monitoring their effects on luminescence in the marine bacterium Photobacterium phosphoreum, Strain NCMB 844. Genotoxicity was analyzed with a dark mutant of this organism whose reversion to the bioluminescent condition is stimulated by compounds attacking guanine sites in deoxyribonucleic acids. In this assay, cyclopiazonic acid, unlike aflatoxin B1, is not enhanced by cyclopiazonic acid when the two mycotoxins are assayed in combination. Cytotoxicity was assessed by the diminution of bioluminescence in a separate assay system with strain NRRLB-1177 of P. phosphoreum. Cyclopiazonic acid is more cytotoxic than aflatoxin B1, and concentrations of cyclopiazonic acid required for cytotoxicity decreases with time, whereas aflatoxin B1 cytotoxic expression does not change significantly with time under most assay conditions. Aflatoxin B1 and cyclopiazonic acid assayed as a dose pair indicate that these mycotoxins elicit their effects by independent modes of action.

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