耐青霉素肺炎链球菌血清型 35B 引起的菌血症和脑膜炎：病例报告，头孢曲松联合万古霉素和利奈唑胺治疗成功。

IF 1 4区医学 Q3 MEDICINE, GENERAL & INTERNAL Internal Medicine Pub Date : 2024-11-08 DOI:10.2169/internalmedicine.3904-24

Mifumi Tomioka, Kiwamu Nakamura, Shaoqing Duan, Kazuaki Matsumoto, Takahiro Shindo, Keisuke Hoshi, Mika Nagao, Fuminari Oshima, Yasuka Hara, Yoshiyuki Namai

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引用次数: 0

摘要

我们在此报告一例由肺炎链球菌血清型 35B 多药耐药性引起的 3 个月大男婴细菌性脑膜炎和菌血症病例。患者入院时静脉注射了氨苄西林。然而，当怀疑患上肺炎球菌脑膜炎时，抗生素治疗改为头孢曲松（CTRX）和万古霉素（VCM）。然而，由于万古霉素难以达到足够的血清谷值水平，治疗再次改为利奈唑胺（LZD）。经过 16 天的 CTRX 和 LZD 治疗后，患者康复，未出现并发症。该病例表明，LZD 是治疗细菌性脑膜炎的一种可行方案。

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Bacteremia and meningitis caused by penicillin-resistant Streptococcus pneumoniae serotype 35B successfully treated with ceftriaxone combined with vancomycin followed by linezolid: A case report.

We herein report a case of bacterial meningitis and bacteremia in a 3-month-old boy caused by Streptococcus pneumoniae serotype 35B multidrug resistance. Intravenous ampicillin was administered on admission. However, when pneumococcal meningitis was suspected, the antibiotic treatment was changed to ceftriaxone (CTRX) and vancomycin (VCM). However, owing to difficulties in achieving sufficient serum trough levels of VCM, this treatment was again switched to linezolid (LZD). The patient recovered without complications after 16 days of CTRX and LZD treatment. This case suggests that LZD is a viable treatment option for bacterial meningitis.

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来源期刊

Internal Medicine 医学-医学：内科

CiteScore

1.90

自引率

8.30%

发文量

审稿时长

2.2 months

期刊介绍： Internal Medicine is an open-access online only journal published monthly by the Japanese Society of Internal Medicine. Articles must be prepared in accordance with "The Uniform Requirements for Manuscripts Submitted to Biomedical Journals (see Annals of Internal Medicine 108: 258-265, 1988), must be contributed solely to the Internal Medicine, and become the property of the Japanese Society of Internal Medicine. Statements contained therein are the responsibility of the author(s). The Society reserves copyright and renewal on all published material and such material may not be reproduced in any form without the written permission of the Society.