在肺孢子菌肺炎中使用棘白菌素联合克林霉素：14 例患者的病例系列。

IF 3.9 2区医学 Q1 INFECTIOUS DISEASES Journal of Antimicrobial Chemotherapy Pub Date : 2024-11-13 DOI:10.1093/jac/dkae379

Idoia Bilbao, Iñigo Pineda Abel de la Cruz, Francisco de Asís Carmona-Torre, Mariano Rodríguez-Mateos, José Ramón Yuste Ara, Jose L Del Pozo

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引用次数: 0

摘要

背景：肺孢子虫肺炎（PcP）是一种机会性感染，其标准疗法是联合三唑。然而，安全性问题和不耐受性可能会影响其效用：目的：评估棘白菌素和克林霉素联合治疗 PcP 的安全性和有效性：我们对14名患者进行了调查，他们接受了包括棘白菌素类和克林霉素在内的不含联合三唑的联合治疗方案：结果：14名患者中有8人获得临床治愈，5人因原发疾病而死亡；但只有1名患者死于PcP：结论：对于无法使用联合新诺明治疗 PcP 的患者，棘白菌素和克林霉素可能是一种安全有效的替代治疗方法。

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Use of echinocandins combined with clindamycin in Pneumocystis pneumonia: a case series of 14 patients.

Background: Pneumocystis jirovecii pneumonia (PcP) is an opportunistic infection for which the standard of care is co-trimoxazole. However, safety concerns and intolerance may compromise its utility.

Objectives: To evaluate the safety and efficacy of the combination of echinocandins and clindamycin to treat PcP.

Patients and methods: We investigated 14 patients treated with a co-trimoxazole-free combined regimen that included echinocandins and clindamycin.

Results: Clinical cure was achieved in 8 out of 14 patients, while 5 had a fatal outcome due to their primary disease; however, only one patient died due to PcP.

Conclusions: Echinocandin and clindamycin may be a safe and effective alternative treatment for patients who cannot be given co-trimoxazole for PcP.

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来源期刊

Journal of Antimicrobial Chemotherapy 医学-传染病学

CiteScore

9.20

自引率

5.80%

发文量

423

审稿时长

2-4 weeks

期刊介绍： The Journal publishes articles that further knowledge and advance the science and application of antimicrobial chemotherapy with antibiotics and antifungal, antiviral and antiprotozoal agents. The Journal publishes primarily in human medicine, and articles in veterinary medicine likely to have an impact on global health.