淀粉样蛋白成像最新进展:淀粉样蛋白前景如何因食品药品管理局近期批准抗淀粉样蛋白治疗药物而发生变化。

IF 1 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Journal of nuclear medicine technology Pub Date : 2024-11-12 DOI:10.2967/jnmt.124.268329
Barbara J Grabher
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引用次数: 0

摘要

核医学与核技术》杂志已经有一段时间没有发表关于淀粉样蛋白成像最佳实践的文章了。鉴于美国食品和药物管理局最近批准了新的抗淀粉样蛋白疗法(AATs)来减少大脑中的淀粉样蛋白斑块并减缓轻度认知障碍的进展,以及为记录淀粉样蛋白斑块而进行的淀粉样蛋白 PET 扫描的数量可能会增加,《核医学与核技术》杂志认为现在是发表一篇关于最佳实践的复习文章的最佳时机。使用淀粉样蛋白正电子发射计算机断层扫描有助于减缓轻度认知障碍的进展,让患者在不得不放弃独立生活、搬到家人家或住进辅助生活设施之前,可以多独立生活一段时间。神经科医生在开具 AATs 处方时必须首先证明患者患有淀粉样蛋白斑块。为此,可以进行淀粉样蛋白正电子发射计算机断层扫描,或通过腰椎穿刺检查脑脊液中的淀粉样蛋白斑块。虽然后者更具成本效益,而且没有相关的辐射暴露,但与淀粉样蛋白 PET 相比,它的侵入性很高。由训练有素的核医学医生解读高质量的淀粉样蛋白 PET 扫描是第一步,也是为痴呆症专家和患者提供有关淀粉样蛋白状态的准确信息的关键,从而为患者管理做出最佳决策。
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Amyloid Imaging Update: How the Amyloid Landscape Is Changing in Light of the Recent Food and Drug Administration Approval of Antiamyloid Therapeutics.

It has been some time since the Journal of Nuclear Medicine and Technology has published an article on best practices in amyloid imaging. In light of the recent Food and Drug Administration approval of new antiamyloid therapies (AATs) to decrease amyloid plaques in the brain and slow progression of mild cognitive impairment, and the potential increase in the number of amyloid PET scans being acquired to document amyloid plaques, the Journal of Nuclear Medicine and Technology felt it was a perfect time to publish a refresher on best practices. AATs are administered to help slow progression of mild cognitive impairment, allowing patients to live independently a little longer before having to give up their independence and move in with family or into an assisted living facility. Neurologists prescribing AATs must first document that the patient has amyloid plaques. To do this, amyloid PET can be performed, or a lumbar puncture can be used to look for amyloid plaques in the cerebrospinal fluid. Although the latter is more cost-effective and has no associated radiation exposure, it is highly invasive compared with amyloid PET. High-quality amyloid PET scans interpretated by a trained nuclear medicine physician are the first step and key to providing the dementia expert and patient with accurate information on amyloid status, allowing for the best decisions on patient management.

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来源期刊
Journal of nuclear medicine technology
Journal of nuclear medicine technology RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
1.90
自引率
15.40%
发文量
57
期刊最新文献
Amyloid Imaging Update: How the Amyloid Landscape Is Changing in Light of the Recent Food and Drug Administration Approval of Antiamyloid Therapeutics. Brain Imaging-PET: Tau. Decoding the Jargon: Understanding the Nomenclature of Clinical Education. Delivery Methods of Radiopharmaceuticals: Exploring Global Strategies to Minimize Occupational Radiation Exposure. SPECT Views for Cardiac Amyloidosis Imaging.
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