应用间充质干细胞发现神经退行性疾病疗法。

IF 3.4 3区环境科学与生态学 Q3 CELL & TISSUE ENGINEERING Regenerative Therapy Pub Date : 2024-10-30 eCollection Date: 2024-06-01 DOI:10.1016/j.reth.2024.09.014

Quynh Dieu Trinh, Huynh Nhu Mai, Duc Toan Pham

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引用次数: 0

摘要

神经退行性疾病是与脑细胞进行性退化有关的中枢或周围神经系统疾病。阿尔茨海默病、帕金森病、亨廷顿病和肌萎缩侧索硬化症等常见的神经退行性疾病已被广泛研究。然而，目前的疗法只能减轻症状，并不能改善这些疾病的发病机制。最近的研究表明，神经炎症、细胞凋亡和氧化应激在神经退行性疾病中发挥作用。间充质干细胞（MSCs）具有抗凋亡、抗炎和抗氧化作用。因此，研究间充质干细胞的作用及其应用可能有助于发现治疗神经退行性疾病的更有效疗法。在本研究中，我们回顾了利用间充质干细胞确定神经退行性疾病疗法的不同方法。

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Application of mesenchymal stem cells for neurodegenerative diseases therapy discovery.

Neurodegenerative diseases are central or peripheral nervous system disorders associated with progressive brain cell degeneration. Common neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis have been widely studied. However, current therapeutics only reduce the symptoms and do not ameliorate the pathogenesis of these diseases. Recent studies suggested the roles of neuroinflammation, apoptosis, and oxidative stress in neurodegenerative diseases. Mesenchymal stem cells (MSCs) exert anti-apoptotic, anti-inflammatory, and antioxidative effects. Therefore, investigating the effects of MSCs and their applications may lead to the discovery of more effective therapies for neurodegenerative diseases. In this study, we review different approaches used to identify therapies for neurodegenerative diseases using MSCs.

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来源期刊

Regenerative Therapy Engineering-Biomedical Engineering

CiteScore

6.00

自引率

2.30%

发文量

106

审稿时长

49 days

期刊介绍： Regenerative Therapy is the official peer-reviewed online journal of the Japanese Society for Regenerative Medicine. Regenerative Therapy is a multidisciplinary journal that publishes original articles and reviews of basic research, clinical translation, industrial development, and regulatory issues focusing on stem cell biology, tissue engineering, and regenerative medicine.