质子射程验证原型与拟人头部模型的中心间比较。

IF 3.3 3区 医学 Q2 ENGINEERING, BIOMEDICAL Physics in medicine and biology Pub Date : 2024-11-11 DOI:10.1088/1361-6560/ad8856
Fernando Hueso-González, Jonathan Berthold, Patrick Wohlfahrt, Thomas Bortfeld, Chirasak Khamfongkhruea, Sebastian Tattenberg, Melek Zarifi, Joost Verburg, Christian Richter
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引用次数: 0

摘要

目的: 在可重复和均衡的条件下,比较两个不同质子治疗中心的两个独立质子量程验证系统的性能。比较两个不同质子治疗中心基于瞬发伽马射线探测器的独立质子范围验证系统在可重复和均衡条件下的性能。方法:在两家质子治疗中心,以校准停止功率的拟人化头部模型作为基础数据,采用可比的治疗方案、光斑位置和能量对其进行辐照。使用临床射束电流、肿瘤轮廓和剂量。绝对范围测量结果与根据基本真相得出的预期值进行比较。每次测量重复十次,以评估统计精度。通过在半场引入 2 毫米和 5 毫米的塑料板,对相对量程偏移的敏感性进行了评估。在所有情况下,绝对测距精度都在 2.4 毫米以内。检测到的相对测距偏差低于 14%。两套系统的性能都值得临床应用于测距偏差的检测。这项研究首次比较了基于伽马射线的独立质子射程验证系统在均衡条件下的实际治疗场和射束电流。
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Inter-center comparison of proton range verification prototypes with an anthropomorphic head phantom.

Objective. To compare in reproducible and equalized conditions the performance of two independent proton range verification systems based on prompt gamma-ray detectors from two different proton therapy centers.Approach. An anthropomorphic head phantom with calibrated stopping power, serving as ground truth, was irradiated with comparable treatment plans, spot positions and energies in both facilities. Clinical beam current, tumor contour and dose were used. The absolute range measurement was compared to the expected value according to the ground truth. The statistical precision was assessed by repeating each measurement ten times. Sensitivity to relative range shifts was evaluated by introducing 2 mm and 5 mm plastic slabs on half of the field.Main results. The resulting absolute range accuracy was within 2.4 mm in all cases. Relative range shifts were detected with deviations lower than 14%.Significance. The performance of both systems was deemed worthy of clinical application for the detection of range deviations. This study represents the first comparison of independent prompt gamma-ray-based proton range verification systems under equalized conditions with realistic treatment fields and beam currents.

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来源期刊
Physics in medicine and biology
Physics in medicine and biology 医学-工程:生物医学
CiteScore
6.50
自引率
14.30%
发文量
409
审稿时长
2 months
期刊介绍: The development and application of theoretical, computational and experimental physics to medicine, physiology and biology. Topics covered are: therapy physics (including ionizing and non-ionizing radiation); biomedical imaging (e.g. x-ray, magnetic resonance, ultrasound, optical and nuclear imaging); image-guided interventions; image reconstruction and analysis (including kinetic modelling); artificial intelligence in biomedical physics and analysis; nanoparticles in imaging and therapy; radiobiology; radiation protection and patient dose monitoring; radiation dosimetry
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