空腹时间为 4-7.9 小时的餐后血浆葡萄糖与美国成年人的癌症死亡率呈正相关。

IF 4.6 2区医学 Q1 ENDOCRINOLOGY & METABOLISM Diabetes/Metabolism Research and Reviews Pub Date : 2024-11-14 DOI:10.1002/dmrr.70008

Yutang Wang, Yan Fang, Andreas J. R. Habenicht, Jonathan Golledge, Edward L. Giovannucci, Antonio Ceriello

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引用次数: 0

摘要

目的：本研究利用美国成年人总体队列调查了餐后血浆葡萄糖（PPG）与癌症死亡率的关系：这项队列研究纳入了1988年至1994年参加第三次全国健康与营养调查的14860名美国成年人，死亡率随访至2019年12月31日。解释变量为血浆葡萄糖水平，包括空腹时间为0-3.9小时（PPG0-3.9h）和4-7.9小时（PPG4-7.9h）的血浆葡萄糖、空腹时间≥8小时（PGfasting）的血浆葡萄糖以及口服葡萄糖耐量试验后2小时的血浆葡萄糖（PG2hOGTT）。采用 Cox 比例危险模型评估了血浆葡萄糖相关癌症死亡风险：结果：PPG4-7.9 小时每增加 1 个自然对数单位，癌症死亡率的多变量调整风险就会增加[危险比 (HR)，3.24；95% 置信区间 (CI)，1.50-7.00]。然而，PPG0-3.9h、PGfasting、PG2hOGTT、血红蛋白 A1c 和胰岛素与癌症死亡率无显著相关性。PPG4-7.9h与癌症死亡率的正相关性仍然存在于既往未确诊癌症的人群中：结论：在美国成年人中，PPG4-7.9h 偏高与癌症死亡风险较高有关。降低 PPG4-7.9h 可降低癌症死亡率。

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Postprandial Plasma Glucose With a Fasting Time of 4–7.9 h Is Positively Associated With Cancer Mortality in US Adults

Aims

This study investigated the association of postprandial plasma glucose (PPG) with cancer mortality using a general cohort of US adults.

Materials and Methods

This cohort study included 14,860 US adults who attended the third National Health and Nutrition Examination Survey from 1988 to 1994, with mortality being followed up until December 31, 2019. The explanatory variable was the level of plasma glucose, including PPG with a fasting time of 0–3.9 h (PPG_0–3.9h) and 4–7.9 h (PPG_4–7.9h), plasma glucose with a fasting time ≥8 h (PG_fasting), and plasma glucose at 2 h after oral glucose tolerance test (PG_2hOGTT). Plasma glucose-associated cancer mortality risk was assessed using Cox proportional hazard models.

Results

A 1-natural-log-unit increase in PPG_4–7.9h was associated with a higher multivariate-adjusted risk for cancer mortality [hazard ratio (HR), 3.24; 95% confidence interval (CI), 1.50–7.00]. However, PPG_0–3.9h, PG_fasting, PG_2hOGTT, haemoglobin A_1c, and insulin were not significantly associated with cancer mortality. The positive association of PPG_4–7.9h with cancer mortality remained in those without a prior diagnosis of cancer.

Conclusions

High PPG_4–7.9h is associated with a higher cancer mortality risk in US adults. Lowering PPG_4–7.9h may reduce cancer mortality.

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来源期刊

Diabetes/Metabolism Research and Reviews 医学-内分泌学与代谢

CiteScore

17.20

自引率

2.50%

发文量

审稿时长

4-8 weeks

期刊介绍： Diabetes/Metabolism Research and Reviews is a premier endocrinology and metabolism journal esteemed by clinicians and researchers alike. Encompassing a wide spectrum of topics including diabetes, endocrinology, metabolism, and obesity, the journal eagerly accepts submissions ranging from clinical studies to basic and translational research, as well as reviews exploring historical progress, controversial issues, and prominent opinions in the field. Join us in advancing knowledge and understanding in the realm of diabetes and metabolism.