用于乙型肝炎模型稳定性分析的多层神经网络方法。

IF 2.6 4区 生物学 Q2 BIOLOGY Computational Biology and Chemistry Pub Date : 2024-11-08 DOI:10.1016/j.compbiolchem.2024.108256
Muhammad Farhan , Zhi Ling , Zahir Shah , Saeed Islam , Mansoor H. Alshehri , Elisabeta Antonescu
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引用次数: 0

摘要

在本研究中,我们通过一个新开发的动力学系统,探讨了乙型肝炎病毒感染这一重大全球健康问题的动态变化。该模型的独特之处在于纳入了无症状携带者以及疫苗接种和治疗策略的影响。与甲型肝炎相比,乙型肝炎对健康的危害更为严重,有些病例会从急性发展为慢性。为了诊断和预测疾病复发,需要计算基本繁殖数(R0)。我们利用 Lyapunov 函数研究了不同条件下疾病动力学的稳定性,以确认我们模型的全局稳定性。我们的研究结果凸显了疫苗接种和早期治疗在减少乙肝病毒传播方面的重要性,使其成为旨在根除乙肝病毒的公共卫生工作的有用工具。在我们的研究中,我们研究了一个以微分方程系统为特征的特定模型的动力学。这项工作利用深度神经网络(DNN)技术提高了模型的准确性,证明了 DNN 在流行病学建模中的应用。此外,我们希望以最小的残余误差找到适合目标解决方案的曲线。我们进行的模拟证明了我们的方法能够准确预测各种条件下的系统行为。我们将 DNN 获得的解决方案与基准解决方案进行比较,并经历测试、验证和训练等阶段,从而对其进行严格测试。为了确定我们方法的准确性和可靠性,我们进行了一系列分析,包括收敛性研究、误差分布评估、回归分析以及每个方程的详细曲线拟合。
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A multi-layer neural network approach for the stability analysis of the Hepatitis B model
In the present study, we explore the dynamics of Hepatitis B virus infection, a significant global health issue, through a newly developed dynamics system. This model is distinguished by its inclusion of asymptomatic carriers and the impact of vaccination and treatment strategies. Compared to Hepatitis A, Hepatitis B poses a more serious health risk, with some cases progressing from acute to chronic. To diagnose and predict disease recurrence, the basic reproduction number (R0) is calculated. We investigate the stability of the disease’s dynamics under different conditions, using the Lyapunov function to confirm our model’s global stability. Our findings highlight the relevance of vaccination and early treatment in reducing Hepatitis B virus spread, making them a useful tool for public health efforts aiming at eradicating Hepatitis B virus. In our research, we investigate the dynamics of a specific model that is characterized by a system of differential equations. This work uses deep neural networks (DNNs) technique to improve model accuracy, proving the use of DNNs in epidemiological modeling. Additionally, we want to find the curves that suit the target solutions with the minimum residual errors. The simulations we conducted demonstrate our methodology’s capability to accurately predict the behavior of systems across various conditions. We rigorously test the solutions obtained via the DNNs by comparing them to benchmark solutions and undergoing stages of testing, validation, and training. To determine the accuracy and reliability of our approach, we perform a series of analyses, including convergence studies, error distribution evaluations, regression analyses, and detailed curve fitting for each equation.
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来源期刊
Computational Biology and Chemistry
Computational Biology and Chemistry 生物-计算机:跨学科应用
CiteScore
6.10
自引率
3.20%
发文量
142
审稿时长
24 days
期刊介绍: Computational Biology and Chemistry publishes original research papers and review articles in all areas of computational life sciences. High quality research contributions with a major computational component in the areas of nucleic acid and protein sequence research, molecular evolution, molecular genetics (functional genomics and proteomics), theory and practice of either biology-specific or chemical-biology-specific modeling, and structural biology of nucleic acids and proteins are particularly welcome. Exceptionally high quality research work in bioinformatics, systems biology, ecology, computational pharmacology, metabolism, biomedical engineering, epidemiology, and statistical genetics will also be considered. Given their inherent uncertainty, protein modeling and molecular docking studies should be thoroughly validated. In the absence of experimental results for validation, the use of molecular dynamics simulations along with detailed free energy calculations, for example, should be used as complementary techniques to support the major conclusions. Submissions of premature modeling exercises without additional biological insights will not be considered. Review articles will generally be commissioned by the editors and should not be submitted to the journal without explicit invitation. However prospective authors are welcome to send a brief (one to three pages) synopsis, which will be evaluated by the editors.
期刊最新文献
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