[产科细胞抢救--背景和实际应用]。

Mischa J Kotlyar, Vanessa Neef, Florian Rumpf, Patrick Meybohm, Kai Zacharowski, Peter Kranke
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摘要

产后出血(PPH)仍然是全球孕产妇死亡的主要原因,过去几十年来,西方国家的发病率不断上升。在此期间,与 PPH 相关的异体红细胞(RBC)输血数量也显著增加。鉴于异体红细胞输血的稀缺性和风险日益增加,而且还与不良产妇结局相关,产科急需优化血液管理策略。近年来,患者血液管理(PBM)越来越多地融入医疗护理中,从而显著改善了患者的预后。细胞抢救(CS)是患者血液管理中的一项节血技术,可在大出血事件中收集、处理和再输患者自身的血液。尽管最近有证据表明,细胞挽救可以大大减少异体红细胞输血的需求并改善患者的预后,但在德国医院的产科中,细胞挽救的使用率仍然很低,仅占围产期出血新生儿的 0.07%。必须假设的是,对患者相关并发症的担忧(如羊水栓塞和母体同种异体免疫)以及对该技术的不熟悉是造成这种犹豫不决的原因。本文概述了产科中使用 CS 及其安全性的现有证据。为了便于实际操作,我们根据维尔茨堡和法兰克福大学医院的经验编写了基本注意事项和组织预防措施,并以图表和核对表的形式介绍了剖宫产手术围术期使用 CS 的情况。
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[Cell salvage in obstetrics-Background and practical implementation].

Postpartum hemorrhage (PPH) remains a leading cause of maternal mortality worldwide, with an increasing incidence in western countries over the past decades. During this period the numbers of PPH-related allogeneic red blood cell (RBC) transfusions have also significantly increased. Given the increasing scarcity and risks of allogeneic RBC transfusions, which are also associated with adverse maternal outcomes, optimized blood management strategies are urgently needed in obstetrics. In recent years, patient blood management (PBM) has been increasingly integrated into medical care, resulting in a significant improvement in patient outcomes. Cell salvage (CS) is one of the PBM blood-sparing techniques that enables the collection, processing and retransfusion of the patient's own blood during major bleeding events. Although recent evidence indicates that CS can significantly reduce the demand for allogeneic RBC transfusions and improve patient outcomes, the utilization in obstetrics in German hospitals remains low, with a usage rate of only 0.07% of births with peripartum hemorrhage. It must be assumed that concerns about patient-related complications, such as amniotic fluid embolism and maternal alloimmunization contribute to this hesitancy, alongside a lack of familiarity with the technique. This article provides an overview of the current evidence on the use and safety of CS in obstetrics. To facilitate a practical implementation, fundamental considerations and organizational precautions were prepared based on the experiences of the University Hospitals in Würzburg and Frankfurt and presented in the form of graphics and checklists for the perioperative use of CS during cesarean sections.

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