用于 DNA 编码文库合成的 DNA 上曼尼希反应

IF 3.3 2区化学 Q1 CHEMISTRY, ORGANIC The Journal of Organic Chemistry Pub Date : 2024-11-01 DOI:10.1021/acs.joc.4c0209810.1021/acs.joc.4c02098

Danila Ryzhikh, Hyewon Seo, Jihoon Lee, Jieon Lee, Myung Hee Nam, Minsoo Song* and Gil Tae Hwang*,

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引用次数: 0

摘要

通过曼尼希反应生成的 β-氨基酮具有作为各种候选药物的巨大潜力。在本研究中，我们优化了 DNA 上曼尼希反应条件，并将其应用于研究 DNA 键合醛与各种胺和酮构建模块的反应。所开发的 DNA 上曼尼希反应保持了 DNA 的完整性，并为文库的生产建立了可行的途径。这些结果凸显了曼尼希反应在 DNA编码文库（DEL）合成中的潜力。

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On-DNA Mannich Reaction for DNA-Encoded Library Synthesis

The β-amino ketones produced through the Mannich reaction hold significant potential as candidates for various drugs. In this study, we optimized on-DNA Mannich reaction conditions and applied them to investigate the reactions of DNA-conjugated aldehydes with various amine and ketone building blocks. The developed on-DNA Mannich reaction preserved the DNA integrity and established viable routes for library production. These results underscore the potential of the Mannich reaction in DNA-encoded library (DEL) synthesis.

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来源期刊

The Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： The Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.