靶向 TUBB3 可抑制前列腺癌的 Anoikis 抗性和骨转移（Adv.）

IF 11 2区医学 Q1 ENGINEERING, BIOMEDICAL Advanced Healthcare Materials Pub Date : 2024-11-11 DOI:10.1002/adhm.202470181

Bingqi Dong, Yanlun Gu, Xiaojiao Sun, Xin Wang, Ying Zhou, Zhuona Rong, Jixin Zhang, Xuedong Shi, Zhuo Zhang, Xu He, Lin Chen, Qingqing Xiong, Xiaocong Pang, Yimin Cui

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引用次数: 0

摘要

前列腺癌骨转移在第2400673号文章中，熊青青、庞晓聪、崔益民及其合作者发现TUBB3是与前列腺癌骨转移相关的关键抗肿瘤预后基因。漂流种子的蒲公英象征着容易转移到骨组织的耐药肿瘤。园丁手持骨靶向脂质纳米粒子，其中封装了靶向 TUBB3 的 siRNA，可减轻前列腺癌骨转移的进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Targeting TUBB3 Suppresses Anoikis Resistance and Bone Metastasis in Prostate Cancer (Adv. Healthcare Mater. 28/2024)

Prostate Cancer Bone Metastasis

In article 2400673, Qingqing Xiong, Xiaocong Pang, Yimin Cui, and co-workers identify TUBB3 as a key anoikis-related prognostic gene correlated with prostate cancer bone metastasis. The dandelion with drifting seeds symbolizes the anoikis-resistant tumor that can easily metastasize to bone tissue. The gardener holds bone-targeting lipid nanoparticles encapsulating siRNA targeting TUBB3 to attenuate the progression of prostate cancer bone metastasis.

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来源期刊

Advanced Healthcare Materials 工程技术-生物材料

CiteScore

14.40

自引率

3.00%

发文量

600

审稿时长

1.8 months

期刊介绍： Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.