仿生纳米调节器可诱导杯突和乳酸耗竭介导的 ROS 风暴，用于透明细胞肾细胞癌的金属免疫疗法（Adv.）

IF 10 2区医学 Q1 ENGINEERING, BIOMEDICAL Advanced Healthcare Materials Pub Date : 2024-11-11 DOI:10.1002/adhm.202470182

Xiaotong Xu, Huimin Li, Binghua Tong, Weijie Zhang, Xiaofei Wang, Yue Wang, Geng Tian, Zhaowei Xu, Guilong Zhang

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引用次数: 0

摘要

纳米免疫疗法特异性代谢重编程引发乳酸在ccRCC中蓄积，成为保护癌细胞免受免疫疗法和化疗的 "护城河"。在第2400204号文章中，田耕、徐兆伟、张桂龙及其合作者开发了一种新型 "降落伞标本"，它伪装在癌细胞膜上，携带特殊武器（乳酸和铜），通过诱导ROS风暴、杯突变和增强免疫治疗，实现对ccRCC的精确打击。

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Biomimetic Nano-Regulator that Induces Cuproptosis and Lactate-Depletion Mediated ROS Storm for Metalloimmunotherapy of Clear Cell Renal Cell Carcinoma (Adv. Healthcare Mater. 28/2024)

Nanoimmunotherapy

Specific metabolism reprogramming triggered lactate accumulation in ccRCC serves as a “moat” to protect cancer cells from immune- and chemotherapies. In article 2400204, Geng Tian, Zhaowei Xu, Guilong Zhang, and co-workers develop a novel “parachute specops”, which are disguised with cancer cell membrane and carry special weapons (LOx and copper), to achieve precise strike for ccRCC through inducing ROS storm, cuproptosis and enhanced immunotherapy.

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来源期刊

Advanced Healthcare Materials 工程技术-生物材料

CiteScore

14.40

自引率

3.00%

发文量

600

审稿时长

1.8 months

期刊介绍： Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.