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引用次数: 0
摘要
通过对源自深海的真菌青霉（Penicillium allii-sativi）进行化学研究，发现了四种新的（1-4）和一种已知的（5）经皮类化合物。化合物 3 能明显阻断 mTOR 信号通路，使 Hela 细胞的细胞周期停滞在 G0-G1 期，并引发线粒体凋亡。而巨噬细胞素 A 则通过激活涉及死亡受体、线粒体、mTOR 和 TNF 的凋亡途径，有效地引发了 MDA-MB-231 癌细胞的细胞死亡。更多详情见第 3283-3292 页 Yang 等人的文章。
A chemical investigation of the deep-sea-derived fungus Penicillium allii-sativi resulted in the discovery of four new (1—4) and one known (5) meroterpenoids. Compound 3 significantly blocked the mTOR signaling pathway, resulting in the arrest of cell cycle at G0-G1 phase and triggering mitochondrial apoptosis in Hela cells. While macrophorin A effectively triggered cell death in MDA-MB-231 cancer cells by activating apoptosis pathways involving death receptors, mitochondria, mTOR, and TNF. More details are discussed in the article by Yang et al. on pages 3283—3292.
期刊介绍：
The Chinese Journal of Chemistry is an international forum for peer-reviewed original research results in all fields of chemistry. Founded in 1983 under the name Acta Chimica Sinica English Edition and renamed in 1990 as Chinese Journal of Chemistry, the journal publishes a stimulating mixture of Accounts, Full Papers, Notes and Communications in English.
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