血卟啉单甲醚光动力疗法治疗葡萄酒色斑的最新进展:更新与启示。

IF 1.8 4区 医学 Q3 DERMATOLOGY Archives of Dermatological Research Pub Date : 2024-11-16 DOI:10.1007/s00403-024-03531-x
Ahmad Taha Khalaf, Yuanyuan Wei, Ahmed N. Abdalla, Wei Fan, Hua Jiang
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引用次数: 0

摘要

葡萄酒港污渍(PWS)是一种先天性血管畸形,其特点是毛细血管畸形,随着时间的推移,颜色会持续加深。包括激光疗法在内的传统治疗方法显示出不同程度的疗效,而且会产生明显的副作用。血卟啉单甲醚-光动力疗法(HMME-PDT)是一种很有前景的替代疗法,它能提供有针对性的治疗,并可能减少不良反应。本文旨在评估 HMME-PDT 作为 PWS 治疗策略的临床疗效和潜力。本文对文献和临床研究进行了全面回顾,以评估 HMME-PDT 在治疗 PWS 中的应用和结果。简要介绍了PWS的性质、治疗中的创新和挑战、HMME-PDT的机制、临床有效性和声像图外观、安全性和长期效果,以及优化治疗的挑战和建议。综述强调了 HMME-PDT 的作用机制,重点是其选择性靶向异常血管的能力。临床评估包括临床和声像图评估,以确定治疗效果。研究结果显示,HMME-PDT 治疗后,血管病变的临床外观和声像图特征均有明显改善。论文还讨论了皮肤镜在 HMME-PDT 应用中的效用、影响疗效的因素、热辅助对 PDT 疗效的影响,以及通过适当的护理处理不良反应。综述强调了 HMME-PDT 作为 PWS 有效治疗方法的巨大潜力,并注意到其在临床和超声评估中的良好效果。不过,它也强调了进一步研究的必要性,以规范治疗方案和评估长期疗效。
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Recent progress in hematoporphyrin monomethyl ether-photodynamic therapy for port-wine stains: updates and insights

Port-wine stains (PWS) are congenital vascular malformations characterized by capillary malformations that persist and often darken over time. Traditional treatment methods, including laser therapy, have shown varying degrees of effectiveness and can be associated with significant side effects. Hematoporphyrin Monomethyl Ether-Photodynamic Therapy (HMME-PDT) has emerged as a promising alternative, offering targeted treatment with potentially fewer adverse effects. This paper aims to evaluate the clinical efficacy and potential of HMME-PDT as a treatment strategy for PWS. It provides a comprehensive review of the literature and clinical investigations to assess the application and outcomes of HMME-PDT in treating PWS. Briefly introduce the nature of PWS, innovations and challenges in treatment, the mechanism of HMME-PDT, clinical effectiveness and sonographic appearance, safety and long-term effects, and challenges and suggestions for optimizing treatment. The review highlights the mechanism by which HMME-PDT works, focusing on its ability to target abnormal blood vessels selectively. Clinical evaluations included clinical and sonographic assessments to determine the efficacy of the treatment. The findings revealed significant improvements in the clinical appearance and sonographic features of vascular lesions following HMME-PDT. The paper also discusses the utility of dermoscopy in HMME-PDT applications, factors affecting treatment efficacy, the impact of thermal assistance on the effectiveness of PDT, and the management of adverse reactions through proper nursing care. The review underscores the considerable potential of HMME-PDT as an effective treatment for PWS, noting its promising outcomes in clinical and sonographic assessments. However, it also emphasizes the need for further research to standardize treatment protocols and assess long-term outcomes.

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来源期刊
CiteScore
4.10
自引率
3.30%
发文量
30
审稿时长
4-8 weeks
期刊介绍: Archives of Dermatological Research is a highly rated international journal that publishes original contributions in the field of experimental dermatology, including papers on biochemistry, morphology and immunology of the skin. The journal is among the few not related to dermatological associations or belonging to respective societies which guarantees complete independence. This English-language journal also offers a platform for review articles in areas of interest for dermatologists and for publication of innovative clinical trials.
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