Kehinde Charles Mofolorunsho, Vinogrin Dorsamy, Chauntelle Bagwandeen, Nathlee Samantha Abbai
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引用次数: 0
摘要
背景：包括淋病奈瑟菌（Ng）和沙眼衣原体（Ct）在内的性传播感染（STI）对男男性行为者（MSM）的影响尤为严重。由于缺乏有关非洲男男性行为者性传播感染的可靠数据，以证据为基础的筛查策略的制定受到了限制。本研究旨在记录撒哈拉以南非洲（SSA）男男性行为者中Ng/Ct的总体流行率：本系统综述根据《系统综述与元分析首选报告项目》（PRISMA）2020 指南进行。检索了以下数据库中的相关文章：PubMed、Scopus、ISI Web of Science 和 Directory of Open Access Journals (DOAJ)。符合条件的研究报告了Ng/Ct在SSA地区MSM人群中的流行情况。采用 Hoy 工具、Doi 图和 LFK 比值对发表偏倚进行了评估。由于研究之间存在异质性，因此使用 Microsoft Excel 的 MetaXL 附加工具进行了亚组分析：在筛选出的 525 篇文章中，有 20 篇被选中纳入研究。其中 6 篇为横断面研究，4 篇为前瞻性队列研究，1 篇为流行病学研究。汇总的男男性行为者Ng/Ct患病率为27%（95% CI，19%-39%），I2为98%，表明研究之间存在异质性。按国家进行的分组分析显示，南非的患病率最高（38%）：释义 在撒哈拉以南非洲地区的男男性行为者中，Ng/Ct 感染的高流行率令人担忧。局限性 由于有关Ng/Ct感染率的数据有限，SSA的真实感染率及其相关风险因素尚不确定：作为第一项系统回顾性传播疾病在 SSA MSM 人口中流行情况的现有文献的研究，该研究表明，Ng/Ct 的负担高于其他地区，因此有必要加强卫生系统，以改善 MSM 人口的教育、检测和治疗：系统综述注册：prospero crd42022327095。
Prevalence of gonococcal and chlamydial infections among men who have sex with men in sub-Saharan Africa: a systematic review and meta-analysis.
Background: Men who have sex with men (MSM) are disproportionately affected by sexually transmitted infections (STI) including Neisseria gonorrhoeae (Ng) and Chlamydia trachomatis (Ct). The lack of robust data on STIs among African MSM has limited the development of evidence-based screening strategies. This study aimed at documenting the pooled prevalence of Ng/Ct among MSM in sub-Saharan Africa (SSA).
Methods: This systematic review was performed according to the Preferred Reporting Items for Systematic Review and Meta-analyses (PRISMA) 2020 guidelines. Relevant articles from the following databases were searched: PubMed, Scopus, ISI Web of Science, and the Directory of Open Access Journals (DOAJ). Eligible studies reported on the prevalence of Ng/Ct among the MSM population in SSA. Publication bias was assessed using the Hoy tool, Doi plot, and LFK ratio. Due to heterogeneity among studies, subgroup analyses were performed using the MetaXL add-on tool for Microsoft Excel.
Results: Of 525 articles screened, 20 were selected for inclusion. Six were cross-sectional, four had a prospective cohort study design, and one was an epidemiological study. The pooled prevalence of Ng/Ct in MSM was 27% (95% CI, 19-39%), with an I2 of 98% signifying heterogeneity among the studies. Subgroup analysis by country revealed South Africa had the highest prevalence (38%).
Discussion: Interpretation The high prevalence of Ng/Ct infection among MSM in SSA is of concern. Limitations Due to limited data available on Ng/Ct prevalence, the true prevalence of SSA and its associated risk factors is uncertain.
Conclusion: As the first study to systematically review the available literature on STI prevalence among the MSM population in SSA, it showed the burden of Ng/Ct is higher than in other regions, warranting the strengthening of health systems to improve education, testing, and treatment in MSM population.
期刊介绍：
Systematic Reviews encompasses all aspects of the design, conduct and reporting of systematic reviews. The journal publishes high quality systematic review products including systematic review protocols, systematic reviews related to a very broad definition of health, rapid reviews, updates of already completed systematic reviews, and methods research related to the science of systematic reviews, such as decision modelling. At this time Systematic Reviews does not accept reviews of in vitro studies. The journal also aims to ensure that the results of all well-conducted systematic reviews are published, regardless of their outcome.
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