Rosannis Brown, Burkhard Beyer, Sophie Knipper, Gisa Mehring, Lars Budäus, Pierre Tennstedt, Markus Graefen, Randi M Pose
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For this purpose, we performed linear regression analyses as well as manual grouping and cluster analyses to identify possible temporal cutoff ranges. The EPIC-26 and the IIEF questionnaires were used for the assessment of UC and EF.</p><p><strong>Results: </strong>We identified 6202 consecutive patients who underwent RP. Neither manual grouping nor cluster analyses showed a significant difference in continence or potency after RP. According to linear regression models, only age was an independent predictor of incontinence (95%-CI 0.006-0.01), and EF before RP (95%-CI 0.22-0.26), age (95%-CI - 0.68 to - 0.5), BMI (95%-CI - 0.66 to - 0.29) and bilateral NS (95%-CI 5.5-2.1) had significant impacts on postoperative EF (all p < 0.001).</p><p><strong>Conclusion: </strong>In the selected patient population, the time interval between prostate biopsy and RP did not seem to have an effect on postoperative functional outcomes (UC and EF).</p>","PeriodicalId":23954,"journal":{"name":"World Journal of Urology","volume":"42 1","pages":"640"},"PeriodicalIF":2.8000,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11569003/pdf/","citationCount":"0","resultStr":"{\"title\":\"Impact of the time interval between biopsy and radical prostatectomy on functional outcomes.\",\"authors\":\"Rosannis Brown, Burkhard Beyer, Sophie Knipper, Gisa Mehring, Lars Budäus, Pierre Tennstedt, Markus Graefen, Randi M Pose\",\"doi\":\"10.1007/s00345-024-05324-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>The aim of our study was to investigate the impact of the time interval between prostate biopsy and radical prostatectomy (RP) on postoperative urinary continence (UC)/erectile function (EF). 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引用次数: 0
摘要
目的:我们的研究旨在探讨前列腺活检与根治性前列腺切除术(RP)之间的时间间隔对术后尿失禁(UC)/勃起功能(EF)的影响。从临床角度来看,间隔数周似乎更有利于手术准备:我们对 2011 年至 2020 年间在一家三级医疗中心接受局部前列腺癌(PCa)RP 治疗的患者进行了回顾性分析。我们评估了以下变量对 RP 术后 1 年 UC 和 EF 的影响:从活检到 RP 的时间、年龄、体重指数、病理 T 分期、EF 和术中神经疏通(单侧与双侧)。为此,我们进行了线性回归分析以及人工分组和聚类分析,以确定可能的时间截断范围。EPIC-26 和 IIEF 问卷用于评估 UC 和 EF:我们确定了 6202 名连续接受 RP 的患者。人工分组和聚类分析均未显示 RP 术后尿失禁或尿失禁率存在显著差异。根据线性回归模型,只有年龄是尿失禁的独立预测因素(95%-CI 0.006-0.01),RP 前的 EF(95%-CI 0.22-0.26)、年龄(95%-CI - 0.68 至 - 0.5)、体重指数(95%-CI - 0.66 至 - 0.29)和双侧 NS(95%-CI 5.5-2.1)对术后 EF 有显著影响(均为 p):在选定的患者群体中,前列腺活检与前列腺癌根治术之间的时间间隔似乎对术后功能预后(UC 和 EF)没有影响。
Impact of the time interval between biopsy and radical prostatectomy on functional outcomes.
Purpose: The aim of our study was to investigate the impact of the time interval between prostate biopsy and radical prostatectomy (RP) on postoperative urinary continence (UC)/erectile function (EF). From a clinical point of view, an interval of several weeks seems to facilitate surgical preparation.
Materials and methods: We retrospectively analyzed patients who underwent RP for localized prostate cancer (PCa) in a tertiary care center between 2011 and 2020. We evaluated the influence of the following variables on UC and EF 1 year after RP: time from biopsy to RP, age, BMI, pathological T-stage, EF and intraoperative nerve sparing (unilateral vs. bilateral). For this purpose, we performed linear regression analyses as well as manual grouping and cluster analyses to identify possible temporal cutoff ranges. The EPIC-26 and the IIEF questionnaires were used for the assessment of UC and EF.
Results: We identified 6202 consecutive patients who underwent RP. Neither manual grouping nor cluster analyses showed a significant difference in continence or potency after RP. According to linear regression models, only age was an independent predictor of incontinence (95%-CI 0.006-0.01), and EF before RP (95%-CI 0.22-0.26), age (95%-CI - 0.68 to - 0.5), BMI (95%-CI - 0.66 to - 0.29) and bilateral NS (95%-CI 5.5-2.1) had significant impacts on postoperative EF (all p < 0.001).
Conclusion: In the selected patient population, the time interval between prostate biopsy and RP did not seem to have an effect on postoperative functional outcomes (UC and EF).
期刊介绍:
The WORLD JOURNAL OF UROLOGY conveys regularly the essential results of urological research and their practical and clinical relevance to a broad audience of urologists in research and clinical practice. In order to guarantee a balanced program, articles are published to reflect the developments in all fields of urology on an internationally advanced level. Each issue treats a main topic in review articles of invited international experts. Free papers are unrelated articles to the main topic.