Marcelo Neto, Beatriz Mendes, Fernando Albuquerque, José António P da Silva
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引用次数: 0
摘要
过去几十年来，我们对类风湿性关节炎（RA）发病机制的认识有了显著提高，随着大量靶向疗法和新治疗策略的出现，RA 的治疗也取得了重大突破。尽管取得了这些进展，但仍有几项需求尚未得到满足，即实现更早和更准确的诊断、监测疾病活动、预测疾病预后和优化治疗。为了弥补这些不足，近期研究的重点是确定可提高诊断精确度、预测疾病预后和优化治疗策略的生物标志物。在这篇叙述性综述中，我们将介绍已证实或有望用于临床的 RA 生物标志物的最新进展。
Novel biomarkers in RA: Implication for diagnosis, prognosis, and personalised treatment.
Over the past decades our understanding of rheumatoid arthritis (RA) pathogenesis has improved remarkably and major breakthroughs in the treatment of RA were made with the advent of numerous targeted therapies and new treatment strategies. Despite these advances, several unmet needs remain, namely in achieving earlier and more accurate diagnosis, monitoring disease activity, predicting disease prognosis and optimizing treatment. To address these gaps, recent research has focused on identifying biomarkers that may enhance diagnostic precision, predict disease prognosis, and optimize treatment strategies. In this narrative review we will describe recent developments in RA biomarkers with demonstrated or promising clinical relevance.
期刊介绍：
Evidence-based updates of best clinical practice across the spectrum of musculoskeletal conditions.
Best Practice & Research: Clinical Rheumatology keeps the clinician or trainee informed of the latest developments and current recommended practice in the rapidly advancing fields of musculoskeletal conditions and science.
The series provides a continuous update of current clinical practice. It is a topical serial publication that covers the spectrum of musculoskeletal conditions in a 4-year cycle. Each topic-based issue contains around 200 pages of practical, evidence-based review articles, which integrate the results from the latest original research with current clinical practice and thinking to provide a continuous update.
Each issue follows a problem-orientated approach that focuses on the key questions to be addressed, clearly defining what is known and not known. The review articles seek to address the clinical issues of diagnosis, treatment and patient management. Management is described in practical terms so that it can be applied to the individual patient. The serial is aimed at the physician in both practice and training.
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