一锅光级联催化：从 N-Arylglycines 和 Morita-Baylis-Hillman (MBH) Acetates 中获得吡咯衍生物。

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC Organic Letters Pub Date : 2024-11-18 DOI:10.1021/acs.orglett.4c04176

Jie Huang, Si-Yu You, Ling-Zhi Hu, Yan-Hong He, Zhi Guan

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One-Pot Photocascade Catalysis: Access to Pyrrole Derivatives from N-Arylglycines and Morita-Baylis-Hillman (MBH) Acetates.

The step-economical synthesis of pyrrole derivatives has posed a challenge in the field of N-heterocyclic chemistry. A novel photocascade catalytic radical S_N2'-type reaction/radical addition/annulation sequence of MBH acetates provides a straightforward route to pyrrole derivatives by forming new C-C, C-N, and C═C bonds in one pot, using N-arylglycines as the α-arylaminomethyl radical precursors for double insertion.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.