含有鸦片制剂和阿片类药物的血液对头发的外源性污染。

IF 2.2 3区 医学 Q1 MEDICINE, LEGAL Forensic science international Pub Date : 2024-11-15 DOI:10.1016/j.forsciint.2024.112298
Alexandre Czech , Julien Scala-Bertola , Elise Pape , Allan Kolodziej , Nathalie Tscheiller , Jean-Yves Jouzeau , Elodie Marchand , Nicolas Gambier
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引用次数: 0

摘要

近年来,毛发毒品分析已广泛用于法医调查。为了最好地解释死后毛发中的药物含量,必须考虑到血液等生物液体的外部污染程度,以避免出现假阳性结果。本研究评估了血液中不同浓度的吗啡(MOR)、6-单乙酰吗啡(6-AM)、可待因(COD)和二氢可待因(DHC)在毛发中的鸦片制剂和阿片类药物含量、在血液中含有不同浓度的吗啡(MOR)、6-单乙酰吗啡(6-AM)、可待因(COD)、双氢可待因(DHC)、曲马多(TRA)、羟考酮(OXY)、美沙酮(MET)、2-亚乙基-1,5-二甲基-3,3-二苯基吡咯烷(EDDP)、丁丙诺啡(BUP)和去甲丁丙诺啡(NBUP)的毛发。被血液短暂浸泡污染的发丝在室温(RT)或 4°C 下分别保存 6 小时、1 天、3 天、7 天或 14 天。经过大量清洗去污后,我们发现所有阿片剂和阿片类药物都在室温和 4 摄氏度下的几小时内融入头发中,随着时间的推移没有发生显著变化。头发中阿片剂和阿片类药物的浓度达到了毛发检测协会(SoHT)为治疗性(MET、COD)或毒性或致死性(所有其他分子)血药浓度设定的临界水平。测定了 NBUP/BUP、MOR/6-AM 和 EDDP/MET 的代谢物与母体药物浓度比,可作为血液外部污染的指标。
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Outside-in hair contamination by blood containing opiates and opioids
Hair analysis for drugs has become extensively used for forensic investigation in recent years. To best interpret hair drug content in post-mortem conditions, the extent of external contamination by biological fluids, such as blood, must be taken into account to avoid false positive results. The present study evaluated opiates and opioids incorporation into hair from blood containing different concentrations of morphine (MOR), 6-mono-acetyl morphine (6-AM), codeine (COD), dihydrocodeine (DHC), tramadol (TRA), oxycodone (OXY), methadone (MET), 2-ethylidene-1,5-dimethyl-3,3- diphenyl pyrrolidine (EDDP), buprenorphine (BUP) and norbuprenorphine (NBUP). The hair strands contaminated by brief soaking into blood were stored at room temperature (RT) or at 4°C during 6 hours, 1, 3, 7 or 14 days. After decontamination by extensive washing, we show that all opiates and opioids were incorporated into hair within a few hours at RT and 4°C, without significant changes over time. The concentrations of opiates and opioids in hair reached the cut-off levels established by the Society of Hair Testing (SoHT) for therapeutic (MET, COD), or toxic or lethal (all other molecules) blood concentrations. The metabolite to parent drug concentration ratios were determined for NBUP/BUP, MOR/6-AM and EDDP/MET and could be helpful as indicators of blood external contamination.
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来源期刊
Forensic science international
Forensic science international 医学-医学:法
CiteScore
5.00
自引率
9.10%
发文量
285
审稿时长
49 days
期刊介绍: Forensic Science International is the flagship journal in the prestigious Forensic Science International family, publishing the most innovative, cutting-edge, and influential contributions across the forensic sciences. Fields include: forensic pathology and histochemistry, chemistry, biochemistry and toxicology, biology, serology, odontology, psychiatry, anthropology, digital forensics, the physical sciences, firearms, and document examination, as well as investigations of value to public health in its broadest sense, and the important marginal area where science and medicine interact with the law. The journal publishes: Case Reports Commentaries Letters to the Editor Original Research Papers (Regular Papers) Rapid Communications Review Articles Technical Notes.
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