突触位置、延迟和背景随机活动对海马 CA1 神经元同步化的影响

Alessandro Fiasconaro , Michele Migliore
{"title":"突触位置、延迟和背景随机活动对海马 CA1 神经元同步化的影响","authors":"Alessandro Fiasconaro ,&nbsp;Michele Migliore","doi":"10.1016/j.csfx.2024.100122","DOIUrl":null,"url":null,"abstract":"<div><div>We study the synchronisation of neurons in a realistic model under the Hodgkin–Huxley dynamics. To focus on the role of the different locations of the excitatory synapses, we use two identical neurons where the set of input signals is grouped at two different distances from the soma. The system is intended to represent a CA1 hippocampal neuron in which the synapses arriving from the CA3 neurons of the trisynaptic pathway appear to be localised in the apical dendritic region and are, in principle, either proximal or distal to the soma. Synchronisation is studied using a specifically defined spiking correlation function as a function of various parameters such as the distance from the soma of one of the synaptic groups, the inhibition weight and the associated activation delay. We found that the neurons’ spiking activity depends nonmonotonically on the relative dendritic location of the synapses and their inhibition weight, while the synchronisation measure always decreases with inhibition, and strongly depends on its activation time delay. In our model, the synaptic random subthreshold background activity substantially reduces synchronisation in a monotonic way, while highlights the importance of a balanced E/I contribution for neuronal synchronisation.</div></div>","PeriodicalId":37147,"journal":{"name":"Chaos, Solitons and Fractals: X","volume":"13 ","pages":"Article 100122"},"PeriodicalIF":0.0000,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of synapse location, delay and background stochastic activity on synchronising hippocampal CA1 neurons\",\"authors\":\"Alessandro Fiasconaro ,&nbsp;Michele Migliore\",\"doi\":\"10.1016/j.csfx.2024.100122\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>We study the synchronisation of neurons in a realistic model under the Hodgkin–Huxley dynamics. To focus on the role of the different locations of the excitatory synapses, we use two identical neurons where the set of input signals is grouped at two different distances from the soma. The system is intended to represent a CA1 hippocampal neuron in which the synapses arriving from the CA3 neurons of the trisynaptic pathway appear to be localised in the apical dendritic region and are, in principle, either proximal or distal to the soma. Synchronisation is studied using a specifically defined spiking correlation function as a function of various parameters such as the distance from the soma of one of the synaptic groups, the inhibition weight and the associated activation delay. We found that the neurons’ spiking activity depends nonmonotonically on the relative dendritic location of the synapses and their inhibition weight, while the synchronisation measure always decreases with inhibition, and strongly depends on its activation time delay. In our model, the synaptic random subthreshold background activity substantially reduces synchronisation in a monotonic way, while highlights the importance of a balanced E/I contribution for neuronal synchronisation.</div></div>\",\"PeriodicalId\":37147,\"journal\":{\"name\":\"Chaos, Solitons and Fractals: X\",\"volume\":\"13 \",\"pages\":\"Article 100122\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-11-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chaos, Solitons and Fractals: X\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2590054424000198\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"Mathematics\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chaos, Solitons and Fractals: X","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2590054424000198","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Mathematics","Score":null,"Total":0}
引用次数: 0

摘要

我们研究了霍奇金-赫胥黎动力学下神经元同步的现实模型。为了重点研究兴奋性突触的不同位置所起的作用,我们使用了两个相同的神经元,在这两个神经元中,一组输入信号被集中在离神经元体两个不同距离的地方。该系统旨在代表一个 CA1 海马神经元,在该神经元中,从三突触通路的 CA3 神经元到达的突触似乎位于顶端树突区域,原则上,这些突触要么靠近神经元体,要么远离神经元体。我们使用一个特定定义的尖峰相关函数来研究同步性,该函数是各种参数的函数,如其中一个突触群与神经元体的距离、抑制权重和相关激活延迟。我们发现,神经元的尖峰活动非单调地依赖于突触的相对树突位置及其抑制权重,而同步度量总是随着抑制而降低,并强烈依赖于其激活时间延迟。在我们的模型中,突触随机阈下背景活动以单调的方式大大降低了同步性,同时突出了均衡的 E/I 贡献对神经元同步性的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Effects of synapse location, delay and background stochastic activity on synchronising hippocampal CA1 neurons
We study the synchronisation of neurons in a realistic model under the Hodgkin–Huxley dynamics. To focus on the role of the different locations of the excitatory synapses, we use two identical neurons where the set of input signals is grouped at two different distances from the soma. The system is intended to represent a CA1 hippocampal neuron in which the synapses arriving from the CA3 neurons of the trisynaptic pathway appear to be localised in the apical dendritic region and are, in principle, either proximal or distal to the soma. Synchronisation is studied using a specifically defined spiking correlation function as a function of various parameters such as the distance from the soma of one of the synaptic groups, the inhibition weight and the associated activation delay. We found that the neurons’ spiking activity depends nonmonotonically on the relative dendritic location of the synapses and their inhibition weight, while the synchronisation measure always decreases with inhibition, and strongly depends on its activation time delay. In our model, the synaptic random subthreshold background activity substantially reduces synchronisation in a monotonic way, while highlights the importance of a balanced E/I contribution for neuronal synchronisation.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Chaos, Solitons and Fractals: X
Chaos, Solitons and Fractals: X Mathematics-Mathematics (all)
CiteScore
5.00
自引率
0.00%
发文量
15
审稿时长
20 weeks
期刊最新文献
Effects of synapse location, delay and background stochastic activity on synchronising hippocampal CA1 neurons Solitary and traveling wave solutions to nematic liquid crystal equations using Jacobi elliptic functions A high-order rogue wave generated by collision in three-component Bose–Einstein condensates Recurrence formula for some higher order evolution equations Finite-time dynamics of the fractional-order epidemic model: Stability, synchronization, and simulations
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1