TNF-α/IL-1β/IL-1α/IL-12炎症细胞因子轴与TLR1/TLR3/TLR5/MYD88免疫信号通路过度激活导致老年患者颈动脉和冠状动脉同时闭塞

IF 3.7 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Cytokine Pub Date : 2024-11-17 DOI:10.1016/j.cyto.2024.156808

Wenhang Zhou , Xia Li , Hualan Zhou , Youdong Hu , Ying Chen , Dianxuan Guo

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引用次数: 0

摘要

背景评估老年患者同时患有颈动脉和冠状动脉疾病的风险因素仍然很困难。本研究旨在确定 TNF-α/IL-1β/IL-1α/IL-12 轴-TLR1/TLR3/TLR5/MYD88 免疫信号通路在老年患者颈动脉闭塞和冠状动脉闭塞并存时的相互作用。分析组包括同时患有颈动脉闭塞和冠状动脉闭塞的患者，健康人作为对照组。研究人员测定了循环中肿瘤坏死因子-α（TNF-α）、白细胞介素-1β（IL-1β）、白细胞介素-1α（IL-1α）、白细胞介素-12（IL-12）、收费样受体1（TLR1）、收费样受体3（TLR3）、收费样受体5（TLR5）和髓样分化因子88（MYD88）的水平。结果颈动脉闭塞+左侧冠状动脉闭塞组的生物标志物（TNF-α、IL-1β、IL-1α、IL-12、TLR1、TLR3、TLR5和MYD88）分别比对照组和颈动脉闭塞+右冠状动脉闭塞组明显升高（P < 0.001），颈动脉闭塞＋左冠状动脉前降支闭塞组分别比颈动脉闭塞＋右冠状动脉闭塞组和颈动脉闭塞＋左冠状动脉环流闭塞组进一步升高（P < 0.001）。结论该研究表明，TNF-α/IL-1β/IL-1α/IL-12轴和TLR1/TLR3/TLR5/MYD88免疫信号通路与老年患者颈动脉闭塞合并冠状动脉闭塞的发病机制有关。

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Background

It remains difficult to evaluate the risk factors for concomitant carotid artery as well as coronary artery diseases in elderly patients. The aim of this research was to determine the TNF-α/IL-1β/IL-1α/IL-12 axes-TLR1/TLR3/TLR5/MYD88 immune signaling pathway interactions in coexistent carotid artery occlusion and coronary artery occlusion in elderly patients.

Methods

Elderly patients, who underwent carotid ultrasonography and coronary computed tomography angiography, were consecutively included in this research. The analyzed groups consisted of those with coexistent carotid artery occlusion and coronary artery occlusion as well as healthy individuals were enrolled as control group. The circulating levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-1α (IL-1α), interleukin-12 (IL-12), toll-like receptor 1 (TLR1), toll-like receptor 3 (TLR3), toll-like receptor 5 (TLR5) and myeloid differentiation factor 88 (MYD88) were measured.

Results

The biomarkers (TNF-α, IL-1β, IL-1α, IL-12, TLR1, TLR3, TLR5 and MYD88) were significantly increased in carotid artery occlusion + left circumflex coronary artery occlusion group when compared with control group and carotid artery occlusion + right coronary artery occlusion group, respectively (P < 0.001), and were further elevated in carotid artery occlusion + left anterior descending coronary artery occlusion group when compared to carotid artery occlusion + right coronary artery occlusion group and carotid artery occlusion + left circumflex coronary artery occlusion group, respectively (P < 0.001).

Conclusion

This research demonstrated that the TNF-α/IL-1β/IL-1α/IL-12 axes and TLR1/TLR3/TLR5/MYD88 immune signaling pathway implicated in the pathogenesis of carotid artery occlusion with coronary artery occlusion in elderly patients.

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来源期刊

Cytokine 医学-免疫学

CiteScore

7.60

自引率

2.60%

发文量

262

审稿时长

48 days

期刊介绍： The journal Cytokine has an open access mirror journal Cytokine: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. * Devoted exclusively to the study of the molecular biology, genetics, biochemistry, immunology, genome-wide association studies, pathobiology, diagnostic and clinical applications of all known interleukins, hematopoietic factors, growth factors, cytotoxins, interferons, new cytokines, and chemokines, Cytokine provides comprehensive coverage of cytokines and their mechanisms of actions, 12 times a year by publishing original high quality refereed scientific papers from prominent investigators in both the academic and industrial sectors. We will publish 3 major types of manuscripts: 1) Original manuscripts describing research results. 2) Basic and clinical reviews describing cytokine actions and regulation. 3) Short commentaries/perspectives on recently published aspects of cytokines, pathogenesis and clinical results.