Zachary H. Paine, Mayank Sharma, Simon H. Friedman
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引用次数: 0
摘要
在文章 10.1002/cbic.202400319 中，西蒙-弗里德曼（Simon H. Friedman）及其合作者展示了一种二锌复合物（绿色圆圈和紫色线条）可以选择性地溶解结晶焦磷酸钙（蓝色圆圈和红色/橙色空间填充结构），同时将骨的主要无机成分羟基磷灰石（青色）溶解到最低程度。它之所以有效，是因为复合物预先组织了静电互补锌离子，然后将结晶钙离子置换出来。焦磷酸钙是影响数百万人的假性痛风的致病因子。
Cover Feature: Selective Dissolution of Calcium Pyrophosphate Dihydrate Crystals Using a Pyrophosphate Specific Receptor (ChemBioChem 21/2024)
In article 10.1002/cbic.202400319, Simon H. Friedman and co-workers have shown that a di-zinc complex (green circles and purple lines) can selectively dissolve crystalline calcium pyrophosphate (blue circles and red/orange space filling structure), while minimally dissolving hydroxy apatite, the main inorganic component of bone (cyan). It is effective because the complex pre-organizes electrostatically complementary zinc ions which then displace the crystalline calcium ions. Calcium pyrophosphate is the causative agent in pseudo-gout, a disease that affects millions.
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ChemBioChem (Impact Factor 2018: 2.641) publishes important breakthroughs across all areas at the interface of chemistry and biology, including the fields of chemical biology, bioorganic chemistry, bioinorganic chemistry, synthetic biology, biocatalysis, bionanotechnology, and biomaterials. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies, and supported by the Asian Chemical Editorial Society (ACES).
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