多巴胺能疗法会干扰帕金森病冲动强迫症患者的决策。

IF 4.4 2区医学 Q1 CLINICAL NEUROLOGY Annals of Clinical and Translational Neurology Pub Date : 2024-11-18 DOI:10.1002/acn3.52249

Fabio Taddeini, Erica Ordali, Alessandra Govoni, Francesca Piattellini, Simone Valente, Luca Caremani, Alberto A Vergani, Ahmet Kaymak, Aldo Rustichini, Eleonora Russo, Chiara Rapallini, Silvia Ramat, Alberto Mazzoni

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引用次数: 0

摘要

冲动-强迫行为（ICB）是帕金森病（PD）常见的非运动症状，通常与多巴胺能药物（DD）治疗有关。我们研究了多巴胺能药物对有 ICB（ICB+）和无 ICB（ICB-）帕金森病患者以及健康对照组（HC）决策的急性影响。参与者进行了两次基于风险的决策任务，其中帕金森病患者分别在接受 DD 治疗之前（DD OFF）和之后（DD ON）进行了测试。在 "DD OFF "状态下，所有组别都制定了风险规避策略。在 DD ON 时，ICB+ 患者（而不是 ICB- 或 HC）会重新做出更冒险的选择。我们的结论是，DD 对 ICB+ 患者的决策具有特定的强烈急性影响。

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Dopaminergic therapy disrupts decision-making in impulsive-compulsive Parkinsonian patients

Impulsive-compulsive behaviors (ICB) are common non-motor symptoms of Parkinson's disease (PD) often associated with dopaminergic drugs (DD) therapy. We investigated the acute effects of DD on decision-making in PD patients with ICB (ICB+) and without it (ICB−), and in healthy controls (HC). Participants performed a risk-based decision-making task twice, with PD patients tested before (DD OFF) and after (DD ON) DD intake. In DD OFF, all groups developed a risk-averting strategy. In DD ON, ICB+ patients (but not ICB− nor HC) reverted to riskier choices. We conclude that DD has a specific strong acute effect on ICB+ patients' decision-making.

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来源期刊

Annals of Clinical and Translational Neurology Medicine-Neurology (clinical)

CiteScore

9.10

自引率

1.90%

发文量

218

审稿时长

8 weeks

期刊介绍： Annals of Clinical and Translational Neurology is a peer-reviewed journal for rapid dissemination of high-quality research related to all areas of neurology. The journal publishes original research and scholarly reviews focused on the mechanisms and treatments of diseases of the nervous system; high-impact topics in neurologic education; and other topics of interest to the clinical neuroscience community.