用于制药的对映体选择性膜:全面回顾。

IF 1.8 4区 医学 Q4 BIOCHEMICAL RESEARCH METHODS Biomedical Chromatography Pub Date : 2024-11-18 DOI:10.1002/bmc.6043
Monti Gogoi, Rajiv Goswami, Akhil Ranjan Borah, Lachit Phukan, Swapnali Hazarika
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引用次数: 0

摘要

过去十年中,手性分离领域取得了重大进展,这对于生物和制药应用至关重要。对映体选择性膜因其独特的性能,如大表面积、可调孔径和高选择性,已成为高效手性分离的理想平台。这些膜能够促进膜材料与手性分子之间的选择性相互作用,因此在分离对映体方面特别有效。本文全面回顾了用于手性分离的对映体选择性膜的最新进展。讨论的主要议题包括各种膜制造方法、功能化方法以及膜特性的表征,特别是在药物输送、生物分子分离和药物分析等应用方面。此外,该综述还探讨了这一快速发展的领域当前面临的挑战、潜在的解决方案和未来前景,并强调了即将开展的研究方向。
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Enantioselective Membranes for Pharmaceutical Applications: A Comprehensive Review

In the past decade, significant advances have been made in the field of chiral separation, which is crucial for biological and pharmaceutical applications. Enantioselective membranes have emerged as a promising platform for efficient chiral separation due to their unique properties such as large surface area, tunable pore size, and high selectivity. These membranes are particularly effective in separating enantiomers because of their ability to facilitate selective interactions between the membrane material and chiral molecules. This article provides a comprehensive review of the recent progress in enantioselective membranes for chiral separation. Key topics discussed include various membrane fabrication methods, functionalization approaches, and the characterization of membrane properties, specifically in the context of applications like drug delivery, biomolecule separation, and pharmaceutical analysis. Furthermore, the review addresses the current challenges, potential solutions, and future prospects in this rapidly evolving field, highlighting the direction for upcoming research.

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来源期刊
Biomedical Chromatography
Biomedical Chromatography 生物-分析化学
CiteScore
3.60
自引率
5.60%
发文量
268
审稿时长
2.3 months
期刊介绍: Biomedical Chromatography is devoted to the publication of original papers on the applications of chromatography and allied techniques in the biological and medical sciences. Research papers and review articles cover the methods and techniques relevant to the separation, identification and determination of substances in biochemistry, biotechnology, molecular biology, cell biology, clinical chemistry, pharmacology and related disciplines. These include the analysis of body fluids, cells and tissues, purification of biologically important compounds, pharmaco-kinetics and sequencing methods using HPLC, GC, HPLC-MS, TLC, paper chromatography, affinity chromatography, gel filtration, electrophoresis and related techniques.
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